This communication confirms the ability of Brenus' next gen immunotherapy, STC-1010, to fight against resistant colorectal tumors with excellent tolerability.
Additionally, multi-omics analysis of STC-1010 batches confirmed consistent quality and batch-to-batch reproducibility, through standardized and scalable production.
STC-1010 was tested in several models extrapolating human conditions (ex-vivo; in-ovo,) using PBMCs from different donors. Results showed a significant immune response activation coupled with a massive and robust tumor killing that has been consistent with our 3 latest STC1010 batches manufactured. Metastasis reduction has also been shown with in-ovo model.
Results show the potential of STC-1010 in clinical settings to treat patients with colorectal cancer causing 9.7 million death per year.
George ALZEEB2, [email protected], Innovation Manager Manager (Ph.D)
Céline GONGORA3, [email protected], Research Director, Head of Team Inserm U1194 "Drug resistances and new cancer treatment" (Ph.D)
Corinne TORTORELLI1, [email protected], Senior Medical Lead (Pharm.D., Ph.D)
Paul BRAVETTI1, [email protected], Chief Executive Officer (Pharm D, MSc)
François GHIRINGHELLI8, [email protected], Head of Team Inserm 1231 TIRECs «Therapies and Immune REsponse in CancerS », Director of early clinical unit CLIPP2, Professor of Oncology (M.D, PhD)
1 STC-1010 is a next-generation cancer immunotherapy produced by Allogeneic STC's proprietary Brenus platform. It's specifically designed to combat colorectal cancer including MSS and MSI-H populations in its first line of treatment for the first indication. STC Platform mimics relapse conditions and allows eduction of patient's immune system against resistant tumor.
2 Brenus Pharma, Lyon, France,
3 INSERM U1194 IRCM, Montpellier, France,
4 CNRS 6302, Dijon, France,
5 Anaquant, Lyon, France
6 Inovotion, La Tronche, France,
7 Explicyte, Bordeaux, France
8 Inserm 1231 CGFL, Dijon, France
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