Le Lézard
Classified in: Health, Science and technology, Covid-19 virus

Applied Biology in Collaboration with Researchers at University Hospital Ramon y Cajal Hospital Announce Results from Study of Androgen Receptor Genetics in Hospitalized COVID-19 Patients


Applied Biology in collaboration with researchers at University Hospital Ramon y Cajal in Madrid, Spain, today announced results from their androgen receptor genetics study in hospitalized COVID-19 male patients (NCT04368897, https://clinicaltrials.gov/ct2/show/NCT04368897?term=androgen&cond=Covid19&draw=2&rank=4). The aim of the study was to confirm a direct association between androgens and COVID-19, potentially paving the way for a breakthrough therapy against SARS-CoV-2.

This prospective longitudinal study analyzed the length of a variable genetic repeat in the androgen receptor gene of hospitalized COVID-19 male patients. The results of the clinical study were published in the Journal of the European Academy of Dermatology and Venerology (doi: 10.1111/jdv.16956).

The study demonstrated that the proportion of male patients admitted to the ICU with the longer variant was statistically significantly higher compared to males with the shorter variant. Similarly, the risk of ICU admissions was significantly higher among males with the longer variant (OR 2.9143). In addition, COVID-19 patients with the shorter variant experienced a shorter duration of hospitalization compared to males with the longer variant (25 days vs 47.5 days). Overall, the longer variant of the androgen receptor was associated with higher disease severity among hospitalized male COVID-19 patients.

The team was led by Andy Goren, MD, Medical Researcher and Co-Investigator with the Department of Dermatology at the University Hospital Ramon y Cajal in Madrid, Spain; Sergio Vañó Galván, MD, from the Department of Dermatology at the University Hospital Ramon y Cajal; Sabina Herrera, MD, from the Infectious Disease Department at the University Hospital Ramon y Cajal; Carlos G. Wambier, MD, PhD, from the Department of Dermatology at the Alpert Medical School of Brown University; and Flavio A. Cadegiani, MD, MSc, PhD, from Corpometria Institute in Brazil.

According to Dr. Sergio Vañó Galván: "To the best of our knowledge, this is the first study to directly confirm an association between androgens and COVID-19 disease severity."

According to Dr. Carlos Wambier: "This is another piece of the puzzle for the scientific understanding of role of androgens in the pandemic."

Further, according to Dr. Andy Goren: "The results of this study further support our research into the use of anti-androgens in the treatment of COVID-19. If randomized prospective trials demonstrate efficacy, anti-androgens may provide a breakthrough inexpensive treatment for COVID-19."

ABOUT APPLIED BIOLOGY

Founded in 2002, Applied Biology, Inc. (www.appliedbiology.com), headquartered in Irvine, California, is a biotechnology company specializing in hair and skin science. Applied Biology develops breakthrough drugs and medical devices for the treatment of androgen mediated dermatological conditions. Applied Biology's R&D pipeline includes a topically applied prophylactic treatment for chemotherapy induced alopecia; a novel diagnostic device that can aid dermatologists in identifying non-responders to topical minoxidil; an adjuvant therapy for non-responders to topical minoxidil; and a novel therapy for female pattern hair loss.


These press releases may also interest you

at 00:00
Annually, World Fish Migration Day raises awareness of migratory fish and threats to their migration on waterways worldwide. This 2020 event will be held on October 24th, with a theme of "Love Flows." Organized by the World Fish Migration Foundation,...

23 oct 2020
The liquid biopsy market is poised to grow by USD 4.02 billion during 2020-2024, progressing at a CAGR of almost 38% during the forecast period. The report on the liquid biopsy market provides a holistic update, market size and forecast, trends,...

23 oct 2020
The dPCR market is poised to grow by USD 518.69 million during 2020-2024, progressing at a CAGR of over 24% during the forecast period. The report on the dPCR market provides a holistic update, market size and forecast, trends, growth drivers, and...

23 oct 2020
The blockchain-based decentralized finance (DeFi) protocol RAI Finance announced that it has succeeded in attracting approximately $1.5 million worth of strategic investment led by global crypto funds including GBIC and Alphabit. Rai Finance is a...

23 oct 2020
The global facial recognition market size is poised to grow by USD 3.35 billion during 2020-2024, progressing at a CAGR of almost 12% throughout the forecast period, according to the latest report by Technavio. The report offers an up-to-date...

23 oct 2020
Canadian Business today ranked Pixieset No. 50 on the 32nd annual Growth List, the definitive ranking of Canada's Fastest-Growing Companies. Produced by Canada's premier business and current affairs media brands, the Growth List ranks Canadian...



News published on 28 september 2020 at 14:10 and distributed by: