Le Lézard
Classified in: Health, Science and technology, Covid-19 virus
Subjects: PDT, TRI

Neutrolis Announces Development Of First-In-Class Treatment Targeting Neutrophil Extracellular Traps (NETs) For Patients With Severe COVID-19

CAMBRIDGE, Mass., Aug. 3, 2020 /PRNewswire/ -- Neutrolis, a biotechnology company developing therapeutics that target neutrophils, the most abundant immune cells in the body, today announced the development of NTR-441, a first-in-class DNASE1L3 enzyme analog that has the potential to rapidly and systemically clear neutrophil extracellular traps (NETs) for severe cases of COVID-19. NETs are a fundamental arm of the immune system and play an important role in chronic and acute diseases.

"We believe NETs are the common factor that explains the mysterious multisystem complications of COVID-19," said Toby Fox, Ph.D., Chief Executive Officer and Co-Founder of Neutrolis. "Our lead compound, NTR-441, and other molecules from our Chromatinasetm platform are the only drugs currently in development that could systemically remove NETs from the body. Thanks in part to competitive funding from the National Institutes of Health (R43HL150944), we will test whether NTR-441 is effective in ARDS, the most lethal manifestation of COVID-19."

Several independent investigators have observed NETs in the lungs of autopsied COVID-19 patients, and observed that NETs biomarkers in patient blood correlate with the clinical severity of COVID-19.

"We just published a study of patients who succumbed to COVID-19 in EBioMedicine published by The Lancet. Surprisingly, we found NETs congesting blood vessels in the lungs of all patients. Clearing these NETs with NTR-441 to restore blood flow may help patients survive COVID-19," said Martin Herrmann, M.D., Ph.D., Professor of Experimental Medicine from the University Hospital Erlangen in Germany, who has studied NETs extensively for the past 15 years.

"NETs may also induce microthrombosis in many organs causing organ failure or strokes. All of these thrombotic events are highly prevalent in COVID-19 patients," said Denisa Wagner, Ph.D., Edwin Cohn Professor of Pediatrics at Boston Children's Hospital (BCH), Harvard Medical School, which licensed Neutrolis some of the intellectual property that underpins the Chromatinasetm platform.

"NETs are a fundamental but unaddressed culprit in a wide array of human diseases. As a critical care specialist and pulmonologist, I think that an efficient therapy against NETs will be important for patients with COVID-19 and other causes of ARDS," said Mark Looney, M.D., Professor of Medicine at University of California, San Francisco and an expert in ARDS.  "If proven safe and effective, NTR-441 could benefit a wide array of patients long after the coronavirus pandemic has ended."

About NTR-441

About NETs

About Neutrolis 
Neutrolis is a biotechnology company developing first-in-class therapies that target neutrophils and their pathogenic products, including NETs. Neutrolis' proprietary platform, Chromatinasetm, is based on the naturally occurring enzymes that break down the extracellular chromatin that form NETs. The company's lead product, NTR-441, is a patented, first-in-class, engineered DNASE1L3 analog with potential application in COVID-19, ARDS, lupus, rheumatoid arthritis, systemic sclerosis and other NET-mediated diseases. Neutrolis has received two competitive LabCentral Golden Ticket awards from Pfizer and Bristol-Myers Squibb. The company is privately held and has been supported to date by First Rice Capital and Prefix Capital, as well as individual investors and funding from the National Institutes of Health. It was founded by Drs. Toby Fox and Abdul Hakkim, two of the earliest and most cited leaders in the NETs field. 

SOURCE Neutrolis

These press releases may also interest you

at 20:10
Forterra, Inc. ("Forterra" or "the Company") , a leading manufacturer of water and drainage infrastructure pipe and products in the United States and Eastern Canada, today announced that on September 29, 2020, Moody's Investors Service ("Moody's")...

at 20:00
ASICS today announces the inaugural ASICS World Ekiden 2020: the ultimate...

at 19:50
Technavio has been monitoring the offshore wind cable market and it is poised to grow by $655.89 mn during 2020-2024, progressing at a CAGR of over 7% during the forecast period. The report offers an up-to-date analysis regarding the current market...

at 19:35
Technavio has been monitoring the nursing education market in US and it is poised to grow by $ 37.62 bn during 2020-2024, progressing at a CAGR of almost 22% during the forecast period. The report offers an up-to-date analysis regarding the current...

at 19:35
TD Ameritrade Holding Corporation today announced that The Toronto-Dominion Bank ("TD Bank") notified The Charles Schwab Corporation ("Schwab") that it has received regulatory approval from the Board of Governors of the Federal Reserve System in...

at 19:28
SIR Royalty Income Fund (the "Fund") and SIR Corp. ("SIR") today reported that SIR and its Lenders entered into amended credit agreements providing extensions to existing waivers and that SIR, the Fund and the SIR Royalty Limited Partnership (the...

News published on 3 august 2020 at 08:11 and distributed by: