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Alzheimer's Drug Discovery Foundation's Diagnostics Accelerator Announces First Digital Biomarker Research Award and Data Sharing Platform

NEW YORK, April 29, 2020 /PRNewswire/ -- The Alzheimer's Drug Discovery Foundation (ADDF) today announced five new research investments through its Diagnostics Accelerator (DxA) initiative, including the first for digital biomarker research to Cogstate Ltd., to develop a technology-based approach for early detection of memory impairment and decline, which can be a sign of Alzheimer's disease. The ADDF also announced a new partnership with Sage Bionetworks to establish an online repository for open data sharing among digital biomarker researchers who receive Diagnostics Accelerator awards.

The up to $1.3 million award to Cogstate Ltd. supports development of a mobile app for early detection of memory problems. Researcher Chris Edgar, Ph.D. is leading a team that is adapting a well-established memory test, called the International Shopping List test, for use on smartphones and tablets. This will make the test accessible to people in their homes and will allow for regular repeat testing to track changes in memory. Cogstate is validating the app to ensure it is effective for use among diverse populations. 

Sage is developing a custom Digital Biomarker Development Platform to store data from funded research and facilitate benchmarking, analysis and sharing among the Diagnostics Accelerator community. Sage's team of data curators, data engineers and analysts will provide awardees with training and support and will maintain the data, making it available to support independent research programs. Data sharing via this platform will also facilitate objective evaluation of ongoing digital biomarker research projects and development of algorithms that support them. Sage will also aim to develop metadata standards and API (Application Program Interface) documentation to facilitate interoperability and integration with other datasets and data platforms in the future.

"Technology advances are giving us new opportunities to develop digital biomarkers ? wearable and other personal devices collect data directly from patients, and their caregivers and families, and cloud computing can collect, collate and analyze this data like never before," said Howard Fillit, M.D., Founding Executive Director and Chief Science Officer of the Alzheimer's Drug Discovery Foundation. "That's why we are so enthusiastic about today's announcements and are looking forward to announcing more digital biomarker awards in the near future."

Supported by leading philanthropists, the Diagnostics Accelerator has mobilized commitments totaling $50 million from ADDF co-founder Leonard A. Lauder, Bill Gates, and additional partners including Jeff Bezos and MacKenzie Bezos, the Dolby family, the Charles and Helen Schwab Foundation, The Association for Frontotemporal Degeneration, and others to address the lack of biomarkers, which are critical toward the ultimate goal: development of effective drugs to prevent and treat Alzheimer's.

Additional investments announced today expand DxA's peripheral biomarker research

The additional investments announced today support development of non-invasive blood tests that can diagnose Alzheimer's earlier than ever before. With the latest investments, the Diagnostics Accelerator has awarded nearly $14 million to 15 investigators around the world who are developing and testing biomarkers for easier, more accurate and earlier diagnosis of Alzheimer's and related dementias.

These research awards, made to researchers working in academia, private enterprise and a government-private partnership working on three continents are:

About the Diagnostics Accelerator
Launched in 2018, the Diagnostics Accelerator research initiative is dedicated to accelerating the development of affordable and accessible biomarkers to diagnose Alzheimer's disease and related dementias and advance the clinical development of more targeted treatments. Through translational research awards and access to consulting support from industry experts, this program will challenge, assist and fund the research community in both academia and industry to develop novel peripheral and digital biomarkers.

Proposals addressing areas of neuroinflammation, synaptic integrity, proteostasis, and vascular injury are of particular interest at this time and applications for both digital and peripheral biomarkers are being accepted on an ongoing basis.

About the Alzheimer's Drug Discovery Foundation
Founded in 1998 by Leonard A. Lauder and Ronald S. Lauder, the Alzheimer's Drug Discovery Foundation is dedicated to rapidly accelerating the discovery of drugs to prevent, treat and cure Alzheimer's disease. The ADDF is the only public charity solely focused on funding the development of drugs for Alzheimer's, employing a venture philanthropy model to support research in academia and the biotech industry. Through the generosity of its donors, the ADDF has granted more than $150 million to fund over 626 programs for Alzheimer's and related dementias in academic centers and biotechnology companies in 19 countries. To learn more, visit: http://www.alzdiscovery.org/.


SOURCE Alzheimer's Drug Discovery Foundation

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