STAINES-UPON-THAMES, United Kingdom, Dec. 7, 2019 /PRNewswire/ -- Mallinckrodt plc (NYSE: MNK), a global biopharmaceutical company, today announced findings on the use of a novel predictive model designed to more quickly identify infants with infantile spasms (IS), a rare seizure disorder that typically occurs between three and seven months of age.1 The study results were reported in a poster presentation titled, "Clinical Pathways Leading to a Diagnosis of Infantile Spasms Using a Claims Database," (Poster #1.209) today during the 2019 Annual Meeting of the American Epilepsy Society (AES) in Baltimore.
The poster can be accessed here on the company's website.
Using claims data from 10.8 million patients under two years of age and input from IS medical experts, researchers developed a predictive model to identify combinations of factors that may best predict IS. The deductive model found that two or more symptoms, including developmental delays, convulsions, dysphagia and cerebral palsy, coupled with a moderate or high severity emergency department (ED) visit, were strong predictors for identification of IS.2
"If we can leverage machine learning algorithms in electronic medical systems, we may be able to identify those children at higher risk of developing infantile spasms, with the possibility of creating alert systems, decreasing time from symptom onset to diagnosis, and ultimately improving outcomes for this potentially devastating form of epilepsy," said Dr. Adam L. Numis, pediatric neurologist and epileptologist, UCSF Benioff Children's Hospital, San Francisco, CA.
Key Findings2
Methods2
Study Limitations2
The analysis was supported by Mallinckrodt.
"We're proud to present this data in support of faster diagnosis of infants during IS Awareness Week, which seeks to raise awareness of the subtle signs of IS that are often overlooked and the urgent need for prompt diagnosis and treatment," said Tunde Otulana, M.D., Chief Medical Officer at Mallinckrodt. "Mallinckrodt is committed to conducting research and providing critical services to help caregivers and infants with IS get the proper diagnosis as quickly as possible to enable earlier treatment intervention with the goal of improving long-term outcomes."
About Infantile Spasms
Infantile spasms, sometimes called West syndrome, is a rare seizure disorder that occurs in approximately 2,000 to 2,500 infants per year in the U.S., based on a review of population-based studies of the condition.1 It most commonly occurs in the first year of life, with peak onset between three and seven months of age.1 Early identification, diagnosis and treatment of infantile spasms are essential to help limit lasting effects.3 Children with infantile spasms generally have one or more of the following symptoms: a certain type of seizure (called "spasms"), a disorganized and chaotic brain-wave pattern called hypsarrhythmia as recorded on an EEG (electroencephalogram), or a failure to meet developmental milestones.3
ABOUT MALLINCKRODT
Mallinckrodt is a global business consisting of multiple wholly owned subsidiaries that develop, manufacture, market and distribute specialty pharmaceutical products and therapies. The company's Specialty Brands reportable segment's areas of focus include autoimmune and rare diseases in specialty areas like neurology, rheumatology, nephrology, pulmonology and ophthalmology; immunotherapy and neonatal respiratory critical care therapies; analgesics and gastrointestinal products. Its Specialty Generics reportable segment includes specialty generic drugs and active pharmaceutical ingredients. To learn more about Mallinckrodt, visit www.mallinckrodt.com.
Mallinckrodt uses its website as a channel of distribution of important company information, such as press releases, investor presentations and other financial information. It also uses its website to expedite public access to time-critical information regarding the company in advance of or in lieu of distributing a press release or a filing with the U.S. Securities and Exchange Commission (SEC) disclosing the same information. Therefore, investors should look to the Investor Relations page of the website for important and time-critical information. Visitors to the website can also register to receive automatic e-mail and other notifications alerting them when new information is made available on the Investor Relations page of the website.
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© 2019 Mallinckrodt. US-1902162 12/19
References
1 Wheless J, Gibson P, Rosbeck K, et al. Infantile spasms (West syndrome): update and resources for pediatricians and providers to share with parents. BMC Pediatrics. 2012;12(1):108. doi:10.1186/1471-2431-12-108. Accessed November 20, 2019.
2 Okimoto D, Dandu H, Maru S, Numis A, Panaccio M, Wan, G, Singh V. Clinical Pathways Leading to a Diagnosis of Infantile Spasms Using a Claims Database. Poster presented at: 2019 American Epilepsy Society (AES) Annual Meeting December 6-10, Baltimore, MD.
3 Go CY, Mackay MT, Weiss SK, et al. Evidence-based guideline update: medical treatment of infantile spasms. Neurology. 2012; 78:1974-1980.
SOURCE Mallinckrodt plc
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