Le Lézard
Classified in: Health, Science and technology
Subjects: TDS, TRI, FVT

/C O R R E C T I O N -- IDEAYA Biosciences, Inc./

In the news release, IDEAYA Biosciences Announces Abstract Summary Results of ASCO 2024 Oral Presentation for Phase 2 Investigator Sponsored Study of Darovasertib in Neoadjuvant Uveal Melanoma, issued 23-May-2024 by IDEAYA Biosciences, Inc. over PR Newswire, we are advised by the company that the percent value pertaining to "median tumor shrinkage (maximum value change)" in the subheadline and 4th paragraph, should read "approximately 45% after 6 months" rather than "approximately 39% after 6 months" as originally issued inadvertently. The complete, corrected release follows:

IDEAYA Biosciences Announces Abstract Summary Results of ASCO 2024 Oral Presentation for Phase 2 Investigator Sponsored Study of Darovasertib in Neoadjuvant Uveal Melanoma

SOUTH SAN FRANCISCO, Calif., May 23, 2024 /PRNewswire/ -- IDEAYA Biosciences, Inc. (Nasdaq: IDYA), a precision medicine oncology company committed to the discovery and development of targeted therapeutics, today announced the publication of the abstract for an oral presentation of preliminary clinical results from its investigator-sponsored Phase 2 trial of darovasertib, a first-in-class oral, small molecular inhibitor of protein kinase C (PKC), as neoadjuvant/adjuvant treatment in uveal melanoma (UM) at the 2024 American Society of Clinical Oncology (ASCO) Annual Meeting.

Anthony Joshua, MBBS, PhD, FRACP, Head Department of Medical Oncology, Kinghorn Cancer Centre, St. Vincent's Hospital in Sydney, who is the leading principal investigator of the Phase 2 study, will present the clinical data from the Phase 2 Neoadjuvant / Adjuvant trial of Darovasertib in Ocular Melanoma" (NADOM) study. Details of the presentation are as follows:

In summary, 15 patients planned for enucleation with localized?UM were treated with darovasertib 300mg twice daily. An initial safety cohort of 3 patients were treated for one month, and the remaining 12 patients were treated in an expansion cohort for up to six months as neoadjuvant treatment prior to their primary intervention (enucleation, plaque brachytherapy or external beam radiotherapy (EBRT)) across three Australian centers.

As of the database lock, 11 patients had completed primary treatment, four remained on neoadjuvant treatment, and six patients received adjuvant darovasertib after primary treatment of their UM with three patients completing the planned six months. At that time, approximately 67% (6 of 9 patients) had confirmed Eye Saved (i.e., converted to plaque brachytherapy or EBRT). Median tumor shrinkage (maximum volume change) was approximately 45% after six months.

The darovasertib monotherapy neoadjuvant treatment was generally well tolerated. Drug-related adverse events (AEs) were predominantly Grade 1 or Grade 2. Thirteen percent of patients reported at least one drug-related Grade 3 adverse event and no drug-related serious adverse events were observed.

Additional patients and further follow up from the abstract summary cut-off date will be presented on the June 3, 2024, ASCO oral presentation. A copy of the ASCO oral presentation will be available at approximately 10:00am CDT at its Investor Relations portal under "Events" (https://ir.ideayabio.com/) on the day of the presentation.

About IDEAYA Biosciences

IDEAYA is a precision medicine oncology company committed to the discovery and development of targeted therapeutics for patient populations selected using molecular diagnostics. IDEAYA's approach integrates capabilities in identifying and validating translational biomarkers with drug discovery to select patient populations most likely to benefit from its targeted therapies. IDEAYA is applying its research and drug discovery capabilities to synthetic lethality ? which represents an emerging class of precision medicine targets.  

Forward-Looking Statements

This press release contains forward-looking statements, including, but not limited to, statements related to the content and timing of the ASCO oral presentation. Such forward-looking statements involve substantial risks and uncertainties that could cause IDEAYA's preclinical and clinical development programs, future results, performance or achievements to differ significantly from those expressed or implied by the forward-looking statements. Such risks and uncertainties include, among others, the uncertainties inherent in the drug development process, including IDEAYA's programs' early stage of development, the process of designing and conducting preclinical and clinical trials, the regulatory approval processes, the timing of regulatory filings, the challenges associated with manufacturing drug products, IDEAYA's ability to successfully establish, protect and defend its intellectual property, and other matters that could affect the sufficiency of existing cash to fund operations. IDEAYA undertakes no obligation to update or revise any forward-looking statements. For a further description of the risks and uncertainties that could cause actual results to differ from those expressed in these forward-looking statements, as well as risks relating to the business of IDEAYA in general, see IDEAYA's Annual Report on Form 10-K dated February 20, 2024 and any current and periodic reports filed with the U.S. Securities and Exchange Commission.

Investor and Media Contact
IDEAYA Biosciences
Andres Ruiz Briseno
SVP, Head of Finance and Investor Relations  
[email protected]

Median tumor shrinkage (maximum volume change) was approximately 45% after six months.

SOURCE IDEAYA Biosciences, Inc.

These press releases may also interest you

16 jun 2024
Mirum Pharmaceuticals, Inc. today announced that it will host an investor call on Monday, June 17 at 8:30 a.m. ET to share interim analysis results from the Volixibat VANTAGE Phase 2b study in primary biliary cholangitis (PBC) and the Volixibat...

16 jun 2024
Eczema, a skin inflammatory disease that causes dry, itchy and inflamed skin, affects millions worldwide. Eczema is associated with an altered skin microbiome and higher colonization by Staphylococcus aureus. The study, led at New York Medical by...

16 jun 2024
Thousands of participants raised $1.63 million at the 11th annual Journey to Conquer Cancer ? a new record for this event, presented by Starlight Investments benefiting the Princess Margaret Cancer Centre on June 16, 2024. This inclusive family and...

16 jun 2024
Please be advised that the Honourable Patty Hajdu, Minister of Indigenous Services, will make a funding announcement for the Weeneebayko Area Health Authority. Date:  Monday, June 17, 2024Time: 12:00 p.m. (ET) Where:House of Commons Foyer (West...

16 jun 2024
Today, Crisis Prevention Institute (CPI) announced the launch of Reframing Behavior ? its new groundbreaking, subscription-based, schoolwide training program that unpacks the latest neuroscience to help all educators build a more positive, supportive...

16 jun 2024
Positive results from the ECHO Phase III trial showed AstraZeneca's CALQUENCE® (acalabrutinib) in combination with bendamustine and rituximab demonstrated a statistically significant and clinically meaningful improvement in progression-free survival...

News published on and distributed by: