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Subject: FDA

FDA Approves First ALS Treatment Funded by Ice Bucket Challenge


The FDA approves AMX0035, the first new treatment for ALS in years. The new treatment was funded by donations from the Ice Bucket Challenge, the 2014 social media phenomenon that swept the globe, with 17 million participants raising $115 million for the ALS Association. The early approval of AMX0035 also comes after a two-year long advocacy effort by the ALS Association and the entire ALS community. AMX0035 slows progression of ALS and extends life.

WASHINGTON, Sept. 29, 2022 /PRNewswire-PRWeb/ -- FDA Approves First ALS Treatment Funded by Ice Bucket Challenge

ALS Association Invested $2.2 Million Raised by Grassroots Social Media Movement into Development and Trial of AMX0035

The ALS Association, the country's largest nonprofit committed to making ALS livable and finding a cure, today celebrated the Food and Drug Administration's (FDA) approval of AMX0035, a new treatment for people living with amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disease. The Association invested $2.2 million of funds raised through the 2014 ALS Ice Bucket Challenge into the development and trial of AMX0035, and led the years-long advocacy campaign that pushed the FDA to approve the treatment prior to completion of an ongoing phase 3 trial.

"We thank the millions of people who donated and participated in the Ice Bucket Challenge, enabling us to invest in promising therapies like AMX0035 that will immediately help people living with ALS," said Calaneet Balas, president and CEO of the ALS Association. "This is a victory for the entire ALS community, which came together to advocate for early approval of AMX0035. We still have a lot of work to do to cure ALS, but this new treatment is a significant step in that fight."

Added Balas: "We are thinking of Pat Quinn and Pete Frates, who championed the Ice Bucket Challenge and changed the trajectory of ALS forever."

In June of 2016, the Association provided Amylyx, the producer of AMX0035, with a $750,000 grant for a clinical trial pilot, and in July of 2016, the Association provided the Northeast ALS Consortium (NEALS) with a $1.46 million grant to help pay for the phase 2 clinical trial of AMX0035. The Association has also provided regulatory, medical, and research counsel to help expedite the progress of AMX0035.

In September of 2020, The ALS Association and I AM ALS submitted over 50,000 signatures to the FDA calling on the agency to approve AMX0035. In subsequent months, the Association held multiple meetings with FDA officials, including a public We Can't Wait Action Meeting in May of 2021, so members of the ALS community could speak directly to FDA officials. The Association also provided scientific and regulatory guidance and in 2022, drove over 14,000 individual emails to the FDA urging approval.

"It's hard to put into words how significant this approval is for the thousands of Americans who are living with ALS and their families," said Larry Falivena, a member of the ALS Association Board of Trustees who was diagnosed with ALS in 2017. "The ALS community has proven that our advocacy can impact decisions that are being made about our health. We need new treatments as quickly as possible if we are going to turn ALS into a livable disease and eventually cure it."

In the summer of 2014, over 17 million people posted Ice Bucket Challenge videos to Facebook, including hundreds of celebrities, athletes, and politicians. The campaign, which was popularized by Pat Quinn and Pete Frates, two young men who were living with ALS, raised over $115 million for the ALS Association. Frates passed away in 2019 and Quinn passed away in 2020.

Balas said: "The approval of AMX0035 is further proof of how the Ice Bucket Challenge dramatically accelerated the fight against ALS. Since then, we've seen new genes discovered, new assistive technology developed to help people living with ALS, and far more people living with ALS have access to care services than ever before."

Since the Ice Bucket Challenge, the ALS Association has spent over $127 million on ALS research and is currently funding 130 research projects in 12 countries. The Association is currently funding 40 potential treatments in the drug development pipeline.

In addition, the Association has expanded its network of clinical providers from 100 Certified Treatment Centers of Excellence, Recognized Treatment Centers, and Affiliated Clinics in 2014 to 188 today.

In 2019, RTI International, an independent research organization, surveyed ALS researchers about the impact of Ice Bucket Challenge resources. RTI reported 84 percent of respondents said support from the Association since the Challenge accelerated their work quite a bit or very much, while 72 percent of respondents said funding from the Association improved their ability to receive additional funding.

About ALS
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease that affects nerve cells in the brain and spinal cord. Over the course of the disease, people lose the ability to move, to speak, and eventually, to breathe. On average, it takes about a year before a final ALS diagnosis is made. The disease is always fatal, usually within five years of diagnosis. There is no cure.

About The ALS Association
The ALS Association is the largest philanthropic funder of ALS research in the world. The Association funds global research collaborations, assists people with ALS and their families through its nationwide network of care and certified clinical care centers, and advocates for better public policies for people with ALS. The ALS Association is working to make ALS a livable disease while urgently searching for new treatments and a cure. For more information about The ALS Association, visit our website at http://www.als.org

CONTACT:
Brian Frederick, Ph.D.
Senior Vice President, Strategic Communications
The ALS Association
202-464-8612
[email protected]

Media Contact

Brian Frederick, ALS Association, 1 20224648612, [email protected]

 

SOURCE ALS Association


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News published on 29 september 2022 at 21:10 and distributed by: