World first clinical data of EO2401, Enterome's first-in-class off-the-shelf OncoMimicstm therapeutic cancer vaccine, to be presented
PARIS, May 27, 2022 /PRNewswire/ -- Enterome, a clinical stage biopharmaceutical company developing first-in-class immunomodulatory drugs based on its bacterial Mimicry drug discovery platform, today announced the publication of three abstracts related to its OncoMimcstm pipeline, including EO2401, its first-in-class off-the-shelf OncoMimicstm cancer immunotherapy, ahead of poster presentations at the American Society of Clinical Oncology (ASCO) Annual Meeting, taking place June 3-7, 2022 in Chicago and virtually.
Enterome will present clinical proof-of-concept data from its most advanced OncoMimicstm drug candidate, EO2401, a therapeutic cancer vaccine candidate currently in clinical development for the treatment of patients with first progression/recurrence of glioblastoma (ROSALIE trial, EOGBM1-18) and for the treatment of patients with locally advanced or metastatic adrenocortical carcinoma, or malignant pheochromocytoma/paraganglioma (SPENCER trial, EOADR1-19).
A third poster describing the Phase 1/2 trial (SIDNEY, EONHL1-20) with Enterome's second OncoMimicstm vaccine, EO2463, in non-Hodgkin lymphoma will also be presented at ASCO.
Details of the poster presentations and session are as follows:
ROSALIE Trial (EOGBM1-18)
SPENCER Trial (EOADR1-19)
SIDNEY Trial (EONHL1-20)
More information on the ASCO 2022 Annual Meeting and related poster presentations can be found at www.asco.org
Contacts
ENTEROME | MEDIA RELATIONS |
Marine Perrier Head of External Communications and Investor Relations | Sylvie Berrebi / Mark Swallow / David Dible MEDiSTRAVA Consulting Tel. +44 207 638 9571 |
About OncoMimicstm Peptides
OncoMimicstm peptides are gut microbiome-derived peptides that closely mimic antigens expressed by tumor cells. In contrast to tumor antigens, however, OncoMimicstm peptides are recognized by the immune system as "non-self" and can generate a strong human cytotoxic CD8+ response steming from memory T cells, offering enormous potential to create a new class of cancer vaccines targeting solid and liquid tumors.
Enterome's pioneering work on its OncoMimicstm pipeline leverages the fundamental understanding that the gut is the largest lymphoid organ in the body and is home to most of its memory T-cells. As a result, there is constant interaction and presentation of peptides and proteins secreted by gut bacteria to the body's immune system, resulting in the formation of a pool of effector memory T cells protecting the human body against bacterial invasion. In the event that the bacterial antigens are mimics of tumor antigens, this process leads to the generation of circulating effector memory T cells with a preserved ability to recognize tumor antigens.
About Enterome
Enterome is a clinical-stage biopharmaceutical company focused on developing breakthrough immunomodulatory drugs for the treatment of cancer and immune diseases. Enterome's pioneering approach to drug discovery is based on its unique and powerful molecular mimicry discovery platform allowing to uncover new biological insights from million of gut bacteria proteins in constant cross-talk with the human body.
Enterome's potentially first-in-class small protein and peptide drug candidates modulate the immune system by closely mimicking the structure, effect or actions of specific antigens, hormones, or cytokines.
Enterome is presently advancing two pipelines of drug candidates, OncoMimicstm and EndoMimicstm, which have the potential to address cancer, inflammatory and autoimmune diseases, respectively:
Enterome employs 65 people and is headquartered in Paris, France. Since its inception, the company has raised a total of ?96 million from Europe- and US-based life science investors and more than ?120 million from pharmaceutical partnerships.
For more information, please visit the company's website at: www.enterome.com
SOURCE Enterome
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