Le Lézard
Classified in: Health, Science and technology, Covid-19 virus
Subjects: Contract/Agreement, Product/Service

Akston Biosciences Announces Commercial Supply Agreement of Seppic's Adjuvant to Formulate Akston Shelf-Stable COVID-19 Vaccine at Global Scale


Akston Biosciences Corporation, a developer of new classes of biologic therapeutics, today announced a commercial agreement with Seppic S.A., a supplier of specialty healthcare ingredients, for the supply of adjuvant for use in Akston's COVID-19 Fc fusion protein vaccine candidate, AKS-452.

Seppic will provide MontanideTM ISA 720 VG adjuvant for use in the vaccine, and is working with Akston to produce 10 million doses of adjuvant by late 2021 and up to 100 million doses per month in 2022. The two companies began collaborating for the development of AKS-452 in the summer of 2020.

AKS-452 is a protein subunit vaccine that is in Phase II testing at the University Medical Center Groningen (UMCG), one of the largest hospitals in the Netherlands. It has been shown to be shelf-stable for at least six months at 25 degrees Celsius (77 degrees Fahrenheit) and it maintains its potency for one month at 37 degrees Celsius (99 degrees Fahrenheit).

"We are excited to work together to combine the great potential of Akston's AKS-452 with Seppic's deep experience in vaccine adjuvants. Seppic is proud to support Akston's temperature-stable COVID-19 vaccine with the supply of its adjuvant and hopes it will be globally available," said Jean-Baptiste Dellon, CEO of Seppic S.A.

Seppic has already started the ramp-up of its adjuvant, in one of its manufacturing facilities in France, to be ready for significant demand.

"We are confident about the potential for AKS-452 to transform the global COVID-19 landscape for those most at risk," said Todd Zion, Ph.D., President & CEO of Akston Biosciences. "There is a clear unmet need for AKS-452, and now, with our close collaboration with Seppic, we have the combined resources, expertise, and determination to meet this need and deliver an effective, affordable, and easily transportable vaccine to the global population."

About AKS-452

Based on Akston's proprietary Fc fusion protein platform, AKS-452 is a CoV-2 protein subunit vaccine designed to induce a Th1/Th2 mixed immune response in patients against the Receptor Binding Domain (RBD) of the novel coronavirus spike protein. Being the primary locus for infection, the RBD is highly conserved among mutated forms of the virus, and preclinical studies have demonstrated robust antibody neutralization of the B.1.1.7 and B.1.351 variants. The vaccine has been engineered to use standard, low-cost, antibody manufacturing techniques, such that a single production line could be capable of producing over one billion doses per year.

About Seppic S.A.

Seppic, an Air Liquide Healthcare company, designs, produces, and distributes for more than 75 years a wide range of specialty ingredients for health and beauty. Present in 100 countries through its subsidiaries and its network of distributors, Seppic employs more than 820 people worldwide, including 110 employees dedicated to innovation. www.seppic.com

About Akston Biosciences

Akston Biosciences Corporation leverages its novel fusion protein platform to develop and manufacture new classes of biologics, including vaccines, ultra-long-acting insulins, and autoimmune disease therapies. Founded by the team that developed the world's first clinical glucose-responsive insulin at SmartCells, Inc. (sold to Merck & Co.), Akston has partnered with Dechra Pharmaceuticals PLC (DPH) to commercialize once-a-week canine and feline insulin therapies. It operates a GMP biologics manufacturing facility and research laboratory at its Beverly, Mass. location. www.akstonbio.com


These press releases may also interest you

16 oct 2021
Core One Labs Inc. , , (the "Company") a research and technology company focused in life sciences and on bringing psychedelic medicines to market through novel delivery systems and psychedelic assisted psychotherapy, congratulates Seattle's city...

16 oct 2021
Neurocrine Biosciences, Inc.  today announced that it will present key information from its movement disorder treatments for Parkinson's disease and tardive dyskinesia (TD) at the American Neurological Association (ANA) 2021 Virtual Annual Meeting...

16 oct 2021
HLNY's highest recognition, the "Award of Distinction" will be presented to Arthur Gianelli, FACHE, Chief Transformation Officer of Mount Sinai Health System and President of Mount Sinai Morningside. This award recognizes a healthcare executive who...

16 oct 2021
Regulated Information ? Inside Information ? UCB, a global biopharmaceutical company, today announced that the U.S. Food and Drug Administration (FDA) has informed the Company that they were unable to complete review of the Biologics License...

16 oct 2021
Throughout the unprecedented COVID-19 pandemic response, the Government of Canada has been providing significant support to provinces and territories. The Minister of Public Safety and Emergency Preparedness, the Honourable Bill Blair, confirmed that...

16 oct 2021
Transplant Québec is thrilled about the joint commitment announced yesterday at the Forum Québec by the provincial government and the three opposition parties. The announcement comes on the eve of World Organ Donation Day and in the wake of the first...



News published on 21 july 2021 at 08:35 and distributed by: