Le Lézard
Classified in: Health
Subjects: SVY, TRI

Large Study shows 230 Times Higher One Year Cancer Risk If Tumor Cell Clusters are Detected in Blood of Normal Individuals - Datar Cancer Genetics


MUMBAI, India and LONDON, Sept. 28, 2020 /CNW/ -- A landmark study published in the American Association of Cancer Research's (AACR) prestigious journal 'Cancer Prevention Research' has shown that it is possible to identify healthy individuals with higher risk of cancer based on a simple blood draw. The study reports that seemingly normal, asymptomatic middle-aged men and women with no history of cancer but having detectable clusters of Circulating Tumor Cells (abbreviated as 'C-ETACs') in their blood have a 230 times higher one year risk of developing cancer as compared to individuals where such clusters were undetectable in blood samples.

Datar Cancer Genetics Logo

In this multi-institutional international collaborative study led by Datar Cancer Genetics, the investigators screened more than 10,000 asymptomatic individuals for detection of C-ETACs and subsequently followed up on these individuals over a period of one year. Simultaneously, blood from more than 4000 cancer patients with various malignancies ('solid organ cancers') was also studied. The study findings revealed that C-ETACs were almost invariably found in cancer patients (> 90%) but were extremely rare (<5%) in normal individuals with no diagnosis or symptom of cancer. Subsequently, over a one-year follow-up, 3.475% of C-ETAC positive normal individuals were diagnosed with various cancers as opposed to 0.015% of C-ETAC negative individuals thus yielding a 230-fold increase in one year risk of cancer diagnosis.

The study is significant because early detection of cancer and risk stratification of seemingly normal individuals remains an ongoing public health challenge. 9.6 million individuals worldwide succumb to cancer each year mainly because of late detection and even the World Health Organization in its 2014 Report has identified early detection as its major objective.

The C-ETAC detection technology and the test are developed by Datar Cancer Genetics using an innovative approach for selective destruction of non-cancer cells in the blood for harvesting C-ETACs. The accuracy of the test is 95.6% and covers more than 20 cancers including Breast, Lung, Ovarian, Stomach, Pancreatic, Colon and Prostate.

Commenting upon the results, Dr Tim Crook, Medical Oncologist at Broomfield Hospital, UK and one of the authors of the paper said that 'C-ETACs are virtually a non-invasive micro-biopsy that will enable high confidence screening and risk stratification of seemingly normal individuals. The technology represents a major advancement for early detection of cancer. The large size of the study is significant.'

The research is published online (https://doi.org/10.1158/1940-6207.CAPR-20-0322) .

About Datar Cancer Genetics

Datar Cancer Genetics is a leading cancer research corporation specialising in non-invasive techniques for better diagnosis, treatment decisions, and management of cancer. The Company's state-of-the-art cancer research centre is ILAC - NABL, ISO, CAP and CLIA ? USA accredited.

For More Information contact

Dr Vineet Datta - [email protected]  
Access Publication of the study at
https://doi.org/10.1158/1940-6207.CAPR-20-0322  
https://datarpgx.com/publications/

Website
datarpgx.com

SOURCE Datar Cancer Genetics Ltd


These press releases may also interest you

at 03:52
The progressive decrease in hearing in elderly people can represent a major problem for their quality of life: it has in fact been demonstrated that critical issues such as these, in addition to being a problem as such, can...

at 00:25
Shanghai Junshi Biosciences Co., Ltd ("Junshi Biosciences," HKEX: 1877; SSE: 688180), a leading innovation-driven biopharmaceutical company dedicated to the discovery, development, and commercialization of novel therapies, announced its financial...

28 mar 2024
The report titled "Central Lab Market by Service Type (Anatomic Pathology/Histology, Biomarker Services, Genetic Services), Phase (Phase 1, Phase 2, Phase 3), Therapeutic Area, End-use - Global Forecast 2024-2030" is now available on...

28 mar 2024
The report titled "Personalized Nutrition Market by Measurement Type (Active Measurement, Standard Measurement), Application (Indication-based, Standard Supplements), Distribution Channel, End-Use - Global Forecast 2024-2030" is now available on...

28 mar 2024
The report titled "Carbon Dioxide Incubator Market by Product (Air Jacketed CO2 Incubators, Direct Heat CO2 Incubators, Water Jacketed CO2 Incubators), Capacity (100-200 Litre, Above 200 Litre, Below 100 Litre), Application, End User - Global...

28 mar 2024
The "Global Clinical In Vitro Diagnostic Medical Laboratory Services Market: Strategy & Trends with Volume & Price Forecasts by Chemistry, Hematology, Microbiology, Pathology, Covid-19, and Molecular Dx by Country. Updated with Impact of COVID-19"...



News published on and distributed by: