Le Lézard
Classified in: Health, Science and technology
Subject: Product/Service

Disarm Therapeutics Reports Preclinical Data Demonstrating Small Molecule SARM1 Inhibitors Preserve Both Axonal Structure and Function In Vitro and In Vivo


Disarm Therapeutics, a biotechnology company creating a new class of disease-modifying therapeutics for patients with axonal degeneration, today announced preclinical data demonstrating that small molecule inhibitors of SARM1 protect axons in both in vitro and in vivo models of axonal degeneration.

"Today's findings are the first reported demonstration of pharmacologic SARM1 inhibition replicating the axonal protection we've previously described in genetic knockout models," said Alvin Shih, M.D., President and CEO of Disarm Therapeutics. "SARM1 is the central driver of axonal degeneration, and today's data further validate that it is an important and also druggable target. This marks significant progress in our development of oral SARM1 inhibitors."

The data, presented today in a poster at the Society for Neuroscience (SfN) Annual Meeting, show that SARM1 inhibitors protect axons, including human iPSC-derived motor axons, in vitro from multiple causes of degeneration, including traumatic, chemotoxic, and mitochondrial insults. In addition, pharmacologic inhibition of SARM1 via oral, small molecule inhibitors prevented axonal degeneration and preserved axonal structure and function in a rodent model of chemotherapy-induced peripheral neuropathy (CIPN). Protection from axonal degeneration was measured using neurofilament light chain (NfL), a downstream biomarker of axonal degeneration that can be detected in blood.

"This is a breakthrough for Disarm and for patients affected by axonal degeneration," said Rajesh Devraj, Ph.D., Chief Scientific Officer and Founder of Disarm Therapeutics. "We are moving rapidly to develop potent, orally active inhibitors of SARM1 to address the fundamental pathological process of axonal degeneration that drives disability progression in patients with diseases such as MS, ALS, and CIPN."

The Disarm SfN 2019 poster can be found here.

About Disarm Therapeutics

Disarm Therapeutics is a biotechnology company that is creating a new class of disease-modifying therapeutics for patients with axonal degeneration, a central driver of neurological disease-causing disability and disease progression. By inhibiting the SARM1 protein, identified by the company's scientific founders as the central driver of axonal degeneration, these therapeutics may prevent the loss of axons in chronic and acute diseases of the central, ocular, and peripheral nervous systems. For a broad range of diseases including multiple sclerosis, amyotrophic lateral sclerosis, glaucoma, and peripheral neuropathies, the therapeutic goal is to prevent further degeneration, stabilize disease, and allow for functional recovery. Disarm was founded by Atlas Venture, Dr. Jeffrey Milbrandt and Dr. Aaron DiAntonio of Washington University in St. Louis, and a team of exceptional scientists and drug developers committed to developing a new treatment paradigm for patients with neurological diseases. For more information, please visit www.disarmtx.com.


These press releases may also interest you

at 21:51
On March 19, DMEGC Solar received the Acknowledgement of Manufacturer's Laboratory Competence issued by TÜV Rheinland, a global certification agency, proving its excellence in PV module R&D and quality control. The acknowledgement is TÜV Rheinland's...

at 21:45
Shop TJC Ltd. (TJC) is thrilled to announce the successful completion of its third collaboration with the iconic BBC...

at 21:32
Arctech has recently signed a contract for the 500MW Manah I power plant project in Oman, following its successful bid for the 588MW Manah II PV project in Oman earlier in 2023. This consecutive project win showcases Arctech's customized solutions...

at 21:15
Techtouch, Inc. (Headquarter: Tokyo, Japan, President/CEO: Naka Imuta) announced today that it ranked 8th in the 21st Technology Fast 50 Japan, with three-year revenue growth of 468.6%. Technology Fast 50 Japan, held annually by Deloitte Tohmatsu...

at 21:00
OKX Ventures, the investment arm of leading crypto exchange and Web3 technology company OKX, today published a report titled 'Unlocking the Infinite Potential of Crypto and AI.' The report explores the convergence of AI and crypto, a major trend in...

at 21:00
The "Strategic Storytelling for Internal Communications: Using the Power of Storytelling to Engage Employees, Manage Organizational Change, and Shape Workplace Cultures" conference has been added to  ResearchAndMarkets.com's offering. The Best...



News published on and distributed by: