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Classified in: Health
Subject: TRI

Roswell Park Moving Unique Immunotherapy Platform Forward With $6.42 Million DoD Grant


BUFFALO, N.Y., Sept. 18, 2019 /PRNewswire-PRWeb/ -- A team from Roswell Park Comprehensive Cancer Center is moving a new three-part strategy for treating advanced cancers forward with support from a U.S. Department of Defense (DoD) grant to Pawel Kalinski, MD, PhD, Vice Chair for Translational Research and Rustum Family Professor for Molecular Therapeutics and Translational Research at the Buffalo, N.Y.-based cancer center. The four-year, $6.42 million Breakthrough Award (award no. W81XWH-19-1-0674/BC180510) through the DoD's Breast Cancer Research Program will fund a clinical trial in patients with brain-metastatic breast cancer, to be led by Shipra Gandhi, MD, Assistant Professor of Oncology in the Department of Medicine at Roswell Park.

The phase II trial, slated to open in 2020, would be the first clinical study to assess the effectiveness of a three-pronged strategy combining distinct immunotherapy approaches:

Alone, these therapies are effective for a limited number of patients, but evidence suggests that together they may help break through a persistent challenge in oncology: how to turn "cold" tumors that don't respond to existing therapies into "hot" ones that the immune system can be trained to recognize and pursue.

"A major limitation of cancer immunotherapy is that tumors adapt to naturally occurring effector cells by shutting down production of the relevant chemokines in the tumor microenvironment," says Dr. Kalinski, the overall Principal Investigator for the project. "Our strategy uses a unique combination of biologic agents to make tumors visible to the immune system by making them look like tissue that's been infected by a virus. We've never tested them all together before in patients, but the findings from earlier clinical and preclinical studies lend strong support for assessing this combination even in the most aggressive and hard-to-treat cancer types."

Three key factors distinguish this platform for combination immunotherapy:

The team will study this approach first in patients with localized brain-metastatic breast cancer (BMBC), or breast cancer that has begun to spread to the brain but is not yet widely disseminated. A companion clinical trial in patients with disseminated, leptomeningeal BMBC, to be led by Peter A. Forsyth, MD, Chair of the Neuro-Oncology Department at Moffitt Cancer Center, in collaboration with Dr. Czerniecki, partnering Principal Investigator on the project, will move forward with additional DoD funding of more than $8 million. Both trials will be available to patients at Roswell Park and at Moffitt.

"There are currently no curative treatments for breast cancer that has spread to and grown in the brain, and the options we have often involve significant side effects or harm to healthy tissues. So this is an area of pronounced clinical need," notes Dr. Gandhi, Principal Investigator on the Roswell Park study. "We're particularly encouraged to be developing a strategy that has the potential to be effective for patients with various breast cancer subtypes ? cancers that are positive for HER2 markers as well as notoriously aggressive triple-negative breast cancers."

Roswell Park has three other studies in progress assessing some of the component elements of this new therapeutic platform:

AIM ImmunoTech Inc. has agreed to provide rintatolimod for the new DoD-funded studies in brain-metastatic breast cancer, as well as these ongoing studies.

Dr. Kalinski gratefully acknowledges earlier support for his work through donations to Roswell Park as a critical foundation that allowed him to pursue and attract outside funding for this work.

The new study in patients with BMBC is not yet open to accrual. For information about other clinical trials currently available at Roswell Park, please visit roswellpark.org/clinical-trials, call 1-800-ROSWELL (1-800-767-9355) or contact Roswell Park by email at [email protected].

This release is also available on the Roswell Park website: https://www.roswellpark.org/media/news/roswell-park-moving-unique-immunotherapy-platform-forward-642-million-dod-grant

Roswell Park Comprehensive Cancer Center is a community united by the drive to eliminate cancer's grip on humanity by unlocking its secrets through personalized approaches and unleashing the healing power of hope. Founded by Dr. Roswell Park in 1898, it is the only National Cancer Institute-designated comprehensive cancer center in Upstate New York. Learn more at http://www.roswellpark.org, or contact us at 1-800-ROSWELL (1-800-767-9355) or [email protected].

 

SOURCE Roswell Park Comprehensive Cancer Center


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