Dicernatm Pharmaceuticals, Inc. (Nasdaq: DRNA) (the "Company" or "Dicerna"), a leading developer of investigational ribonucleic acid interference (RNAi) therapeutics, today reported financial results for the second quarter ended June 30, 2019 and provided a corporate update.
"Dicerna is dynamically growing as we move into pivotal development of our lead program in primary hyperoxaluria with an eye toward commercialization. Simultaneously, we're increasing clinical development and discovery efforts for our own proprietary programs and those in conjunction with our corporate collaborators while expanding the reach of our GalXC RNAi technology," said Douglas Fambrough, Ph.D., president and chief executive officer of Dicerna. "I'm particularly pleased with the strength and depth of the new leaders who have joined Dicerna to drive these efforts. Notably, Dr. Bernd Hoppe, a renowned global expert in the treatment of primary hyperoxaluria, has joined us as vice president of global medical affairs, and we're also joined by Rob Ciappenelli as chief commercial officer, Steven Kates as vice president of regulatory affairs, and Dave Caponera as head of patient advocacy and patient services. With these individuals and the rest of our team, we are confident that we will achieve our milestones and deliver innovative and effective therapies to patients in need."
Recent Clinical and Regulatory Highlights
Upcoming Clinical and Regulatory Milestones
Financial Condition and Operating Results for the Second Quarter of 2019
Guidance
Dicerna believes that its current cash, cash-equivalents, and held-to-maturity investments will be sufficient to fund the execution of its current clinical and operating plan beyond 2020, which includes advancing DCR-PHXC through late-stage clinical development and regulatory filing, completing the proof-of-concept study of DCR-HBVS in participants with HBV, and advancing the Company's DCR-A1AT program through the initial clinical study. This estimate assumes no new funding from additional collaboration agreements or from external financing events and no significant unanticipated changes in costs and expenses. Dicerna expects its overall R&D expense to continue to increase for the foreseeable future, primarily as the Company completes clinical manufacturing activities, advances preclinical toxicology studies, continues clinical activities associated with its lead product candidates, and increases activities under the Lilly, Alexion, and BI agreements.
Conference Call
Management will host a conference call at 4:30 p.m. ET today to review Dicerna's second quarter 2019 financial results and provide a general business update. The conference call can be accessed by dialing (855) 453-3834 or +1 (484) 756-4306 (international) and referencing conference ID 6279126 prior to the start of the call. The call will also be webcast via the Internet and will be available under the "Investors & Media" section of the Dicerna website, www.dicerna.com. A replay of the call will be available approximately two hours after the completion of the call and will remain available for seven days. To access the replay, please dial (855) 859-2056 or (404) 537-3406 and refer to conference ID 6279126. The webcast will also be archived on Dicerna's website.
About Dicernatm Pharmaceuticals, Inc.
Dicernatm Pharmaceuticals, Inc. ("we", "us," "our," "the Company," or "Dicerna") is a biopharmaceutical company using ribonucleic acid (RNA) interference (RNAi) to develop medicines that silence genes that cause disease. The Company's proprietary GalXCtm technology is being applied to develop potent, selective, and safe RNAi therapies to treat diseases involving the liver, including rare diseases, chronic liver diseases, cardiovascular diseases, and viral infectious diseases. Dicerna aims to treat disease by addressing the underlying causes of illness with capabilities that extend beyond the liver to address a broad range of diseases, focusing on target genes where connections between gene and disease are well understood and documented. Dicerna intends to discover, develop, and commercialize novel therapeutics either on its own or in collaboration with pharmaceutical partners. Dicerna has strategic collaborations with Eli Lilly and Company (Lilly), Alexion Pharmaceuticals, Inc. (Alexion), and Boehringer Ingelheim International GmbH (BI). For more information, please visit www.dicerna.com.
About GalXCtm
GalXCtm is a proprietary technology platform invented by Dicerna to discover and develop RNAi-based therapies designed to silence disease-driving genes in the liver. Compounds produced via GalXC are intended to be broadly applicable across multiple therapeutic areas involving the liver, including rare diseases, chronic liver diseases, cardiovascular diseases, and viral infectious diseases. Using GalXC, Dicerna scientists attach N-acetylgalactosamine sugars directly to the extended region of the Company's proprietary RNAi molecules, yielding multiple proprietary conjugate delivery configurations. Many of the conjugates produced via GalXC incorporate a folded motif known as a tetraloop in the extended region. The tetraloop configuration, which is unique to Dicerna's GalXC compounds, allows flexible and efficient conjugation to the targeting ligands and stabilizes the RNAi duplex, which the Company believes will enable subcutaneous delivery of its RNAi therapies to hepatocytes in the liver, where they are designed to specifically bind to receptors on target cells, potentially leading to internalization and access to the RNAi machinery within the cells. The technology may offer several distinct benefits, as suggested by strong preclinical data. The benefits seen in preclinical studies include: potency that is on par with or better than comparable platforms, highly specific binding to gene targets, long duration of action, and an infrequent subcutaneous dosing regimen.
Cautionary Note on Forward-Looking Statements
This press release includes forward-looking statements. Such forward-looking statements are subject to risks and uncertainties that could cause actual results to differ materially from those expressed or implied in such statements. Examples of forward-looking statements include, among others, statements we make regarding: (i) the therapeutic and commercial potential of DCR-PHXC, DCR-HBVS, DCR-A1AT, and the GalXCtm platform; (ii) research and development plans and timelines related to DCR-PHXC, DCR-HBVS, DCR-A1AT, and GalXC; (iii) the potential of Dicerna's technology and drug candidates in the Company's research and development pipeline, and (iv) Dicerna's financial position and cash runway. The process by which an early stage investigational therapy such as DCR-PHXC, DCR-HBVS, DCR-A1AT, and an early stage platform such as GalXC could potentially lead to an approved product is long and subject to highly significant risks. Applicable risks and uncertainties include those relating to Dicerna's clinical research and other risks identified under the heading "Risk Factors" included in the Company's most recent Form 10-Q filing and in other future filings with the Securities and Exchange Commission. These risks and uncertainties include, among others, the cost, timing, and results of preclinical studies and clinical trials and other development activities; the likelihood of Dicerna's clinical programs being executed on timelines provided and reliance on the Company's contract research organizations and predictability of timely enrollment of subjects and patients to advance Dicerna's clinical trials; the potential for future data to alter initial and preliminary results of early stage clinical trials; the future agreement on clinical endpoints for all forms of PH, the unpredictability of the duration and results of the regulatory review of Investigational New Drug Applications (NDAs) and Clinical Trial Applications that are necessary to continue to advance and progress the Company's clinical programs and the regulatory review of NDAs; market acceptance for approved products and innovative therapeutic treatments; competition; the possible impairment of, inability to obtain, and costs to obtain intellectual property rights; possible safety or efficacy concerns that could emerge as new data are generated in R&D; and general business, financial, and accounting risks and litigation. The forward-looking statements contained in this press release reflect Dicerna's current views with respect to future events, and Dicerna does not undertake and specifically disclaims any obligation to update any forward-looking statements.
Dicernatm, GalXCtm, and PHYOXtm are trademarks of Dicerna Pharmaceuticals, Inc.
DICERNA PHARMACEUTICALS, INC. SELECTED FINANCIAL INFORMATION (UNAUDITED) |
||||||||
Condensed Consolidated Balance Sheets | June 30, |
December 31, |
||||||
(In thousands, except share data) | 2019 |
2018 |
||||||
Cash and cash equivalents | $ |
100,321 |
$ |
54,239 |
||||
Held-to-maturity investments | 244,969 |
248,387 |
||||||
Contract receivables | ? | 100,000 |
||||||
Prepaid expenses and other current assets | 4,958 |
2,888 |
||||||
Property and equipment, net | 4,915 |
2,718 |
||||||
Right-of-use asset | 2,627 |
? | ||||||
Restricted cash equivalents | 3,544 |
744 |
||||||
Other noncurrent assets | 62 |
65 |
||||||
Total Assets | $ |
361,396 |
$ |
409,041 |
||||
Accounts payable | $ |
5,636 |
$ |
5,013 |
||||
Accrued expenses and other current liabilities | 10,515 |
9,649 |
||||||
Lease liability, current | 1,648 |
? | ||||||
Litigation settlement payable | ? | 10,500 |
||||||
Deferred revenue, current | 78,073 |
68,893 |
||||||
Lease liability, noncurrent | 1,035 |
? | ||||||
Deferred revenue, noncurrent | 104,324 |
114,293 |
||||||
Total stockholders' equity | 160,165 |
200,693 |
||||||
Total Liabilities and Stockholders' Equity |
$ |
361,396 |
$ |
409,041 |
||||
Common stock outstanding | 68,360,051 |
68,210,742 |
||||||
|
|
|||||||
Condensed Consolidated Statements of Operations | Three Months Ended |
Three Months Ended |
||||||
(In thousands, except per share data) | June 30, 2019 |
June 30, 2018 |
||||||
Revenue from collaborative arrangements | $ |
5,682 |
$ |
1,545 |
||||
Operating expenses: | ||||||||
Research and development | 22,832 |
10,339 |
||||||
General and administrative | 8,831 |
4,760 |
||||||
Litigation expense | ? | 22,244 |
||||||
Total operating expenses | 31,663 |
37,343 |
||||||
Loss from operations | (25,981 |
) |
(35,798 |
) |
||||
Other income (expense): | ||||||||
Interest income | 2,136 |
330 |
||||||
Interest expense | ? | (176 |
) |
|||||
Total other income, net | 2,136 |
154 |
||||||
Net loss | $ |
(23,845 |
) |
$ |
(35,644 |
) |
||
Net loss per share ? basic and diluted | $ |
(0.35 |
) |
$ |
(0.68 |
) |
||
Weighted average common shares outstanding ? basic and diluted | 68,323,850 |
52,555,751 |
||||||
Condensed Consolidated Statements of Operations | Six Months Ended | Six Months Ended | ||||||
(In thousands, except per share data) | June 30, 2019 |
June 30, 2018 |
||||||
Revenue from collaborative arrangements | $ |
8,789 |
$ |
3,090 |
||||
Operating expenses: | ||||||||
Research and development | 44,435 |
20,232 |
||||||
General and administrative | 18,507 |
9,095 |
||||||
Litigation expense | ? | 25,428 |
||||||
Total operating expenses | 62,942 |
54,755 |
||||||
Loss from operations | (54,153 |
) |
(51,665 |
) |
||||
Other income (expense): | ||||||||
Interest income | 4,154 |
619 |
||||||
Interest expense | ? | (176 |
) |
|||||
Total other income, net | 4,154 |
443 |
||||||
Net loss | $ |
(49,999 |
) |
$ |
(51,222 |
) |
||
Net loss per share ? basic and diluted | $ |
(0.73 |
) |
$ |
(0.98 |
) |
||
Weighted average common shares outstanding ? basic and diluted | 68,292,212 |
52,141,849 |
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