OnKure Executes License and Option Agreement with KDAc Therapeutics

OnKure, Inc., the leader in discovery and development of selective histone deacetylase inhibitors, entered into an exclusive license and option agreement with Massachusetts-based KDAc Therapeutics, Inc. to support the continued development of KDAc's selective histone deacetylase 3 (HDAC3) inhibitor program.

The collaboration will focus on the continued advancement of KDAc's lead candidate, KDAc-0001 (or OKI-422), which is licensed from the Broad Institute of MIT and Harvard. Histone deacetylase (HDAC) inhibitors are a class of anti-cancer agents that play important roles in epigenetic and non-histone protein regulation, including death, apoptosis, and cell cycle arrest in cancer cells. OKI-422 is designed to enhance the therapeutic benefit of targeted anti-cancer agents, including anti-checkpoint therapies through restoration of antigen presentation in genetically defined cancers driven by histone acetyl transferase (HAT) loss of function.

"KDAc's experienced team and collaborative efforts resulted in the development of a very unique asset," said Tony Piscopio, Ph.D., Co-founder, President and Chief Executive Officer of OnKure. Piscopio added, "We are looking forward to adding KDAc-0001 to our portfolio of first in class and best in class drug candidates."

"OnKure's experience and proven track record in epigenetic drug development synergize with KDAc's insights in HDAC biology and discovery of highly selective inhibitors," said Edward Holson, Ph.D., Founder, Director and Chief Scientific Officer of KDAc.

About OnKure

OnKure, Inc. is a biopharmaceutical company focused on the discovery and development of targeted small molecule drugs to improve the outcomes of patients afflicted with cancer. OnKure's drug candidates aim to treat patients by targeting malignant cells directly, by working in combination with other small molecule therapies and by priming the tumor microenvironment such that checkpoint inhibition is optimized. For more information about OnKure, please visit www.onkuretherapeutics.com.

About KDAc Therapeutics

KDAc Therapeutics is a biotechnology company founded on technologies licensed from the Broad Institute of MIT and Harvard to translate discoveries in lysine acetylation and epigenetic regulation into novel treatments for cancer patients.