Le Lézard
Classified in: Health, Science and technology, Business
Subjects: ERN, CCA, TRI

Audentes Therapeutics Reports Fourth Quarter 2017 and Full Year Financial Results and Provides Corporate Update



SAN FRANCISCO, March 8, 2018 /PRNewswire/ -- Audentes Therapeutics, Inc. (Nasdaq: BOLD), a biotechnology company focused on developing and commercializing innovative gene therapy products for patients living with serious, life-threatening rare diseases, today reported its financial results for the fourth quarter and full year ended December 31, 2017 and provided an update on the company's recent achievements and anticipated upcoming milestones.

"2017 was a transformational year marked by significant achievements across our portfolio of gene therapy product candidates," stated Matthew R. Patterson, President and Chief Executive Officer.  "Among our many accomplishments, we are particularly pleased to have recently reported positive interim data from the first dose cohort of patients in ASPIRO, the Phase 1/2 clinical study of our product candidate AT132 to treat XLMTM.  These promising initial data add to the growing body of evidence of the utility of AAV-based gene therapy to treat rare neuromuscular diseases, and we are optimistic that they signal a turning point in our ability to bring meaningful benefit to patients and families living with XLMTM."        

Mr. Patterson continued, "As we look forward to the year ahead, we are excited by our many anticipated upcoming pipeline catalysts, including sharing additional data from our ASPIRO study in XLMTM, new data from our VALENS study in Crigler-Najjar, and advancing additional product candidates into the clinic for Pompe disease and CASQ2-CPVT. With our recently completed follow-on offering, we are well capitalized to continue our mission to develop transformative gene therapy products for patients living with serious, life-threatening rare diseases."

Recent Achievements & Upcoming Key Events

Fourth Quarter and Full Year 2017 Financial Results

Conference Call
At 4:30 p.m. Eastern Time today, Audentes management will host a conference call and a simultaneous webcast to discuss its fourth quarter 2017 financial results and provide a corporate update. To access a live webcast of the conference call, please visit the Events & Presentations page within the Investors + Media section of the Audentes website at www.audentestx.com.  Alternatively, please call 1-833-659-8620 (U.S.) or 1-409-767-9247 (international) and dial the conference ID 5890848 to access the call. 

A replay of the webcast will be available on the Audentes website for approximately 30 days.

About Audentes Therapeutics, Inc.
Audentes Therapeutics (Nasdaq: BOLD) is a biotechnology company focused on developing and commercializing innovative gene therapy products for patients living with serious, life-threatening rare diseases.  We are currently conducting Phase 1/2 clinical studies of our lead product candidates AT132 for the treatment of X-Linked Myotubular Myopathy (XLMTM) and AT342 for the treatment of Crigler-Najjar Syndrome.  We have two additional product candidates in development, including AT982 for the treatment of Pompe disease, and AT307 for the treatment of the CASQ2 subtype of Catecholaminergic Polymorphic Ventricular Tachycardia (CASQ2-CPVT).  We are a focused, experienced and passionate team committed to forging strong, global relationships with the patient, research and medical communities.

For more information regarding Audentes, please visit www.audentestx.com.

Forward Looking Statements
This press release contains forward-looking statements within the meaning of the "safe harbor" provisions of the Private Securities Litigation Reform Act of 1995, including, but not limited to: anticipated clinical milestones, the timing and nature of clinical development activities, the timing of the release of data from ongoing clinical trials, the timing of regulatory filings, the expected benefits of the company's product candidates and the use and adequacy of cash reserves.  All statements other than statements of historical fact are statements that could be deemed forward-looking statements. Although the company believes that the expectations reflected in such forward-looking statements are reasonable, the company cannot guarantee future events, results, actions, levels of activity, performance or achievements, and the timing and results of biotechnology development and potential regulatory approval is inherently uncertain. Forward-looking statements are subject to risks and uncertainties that may cause the company's actual activities or results to differ significantly from those expressed in any forward-looking statement, including risks and uncertainties related to the company's ability to advance its product candidates, obtain regulatory approval of and ultimately commercialize its product candidates, the timing and results of preclinical and clinical trials, fund development activities and achieve development goals, establish and scale-up manufacturing processes that comply with regulatory requirements, protect intellectual property and other risks and uncertainties described under the heading "Risk Factors" in documents the company files from time to time with the Securities and Exchange Commission. These forward-looking statements speak only as of the date of this press release, and the company undertakes no obligation to revise or update any forward-looking statements to reflect events or circumstances after the date hereof.

Selected Financial Information

Operating Results:
(amounts in thousands, except share and per share data)


Three months ended December 31,


Year ended December 31,


2017


2016


2017


2016


Unaudited











Operating expenses:








Research and development

$      21,671


$      16,599


$      75,902


$      48,770

General and administrative

5,210


3,233


17,275


11,276

Total operating expenses

26,881


19,832


93,177


60,046

Loss from operations

(26,881)


(19,832)


(93,177)


(60,046)

      Interest income

284


167


767


472

      Other income (expense), net

(24)


(11)


(74)


(94)

Loss before income taxes

(26,621)


(19,676)


(92,484)


(59,668)

      Income tax benefit

2,246


-


2,246


-

Net Loss

$    (24,375)


$    (19,676)


$    (90,238)


$    (59,668)

















Net loss per share, basic and diluted

$        (0.82)


$        (0.91)


$        (3.40)


$        (5.59)

Shares used in computing net loss per share, basic and diluted

29,847,934


21,726,223


26,578,162


10,673,559

 

Selected Balance Sheet Information:
(amounts in thousands)


December 31,


December 31,


2017


2016













Cash, cash equivalents and short-term investments

$      133,605


$      104,883

Total assets

$      178,662


$      142,057

Total liabilities

$        22,064


$        22,686

Total stockholders' equity

$      156,598


$      119,371

 

Audentes Contacts:

Investor Contact:
Andrew Chang
415.818.1033
achang@audentestx.com

Media Contact:
Paul Laland
415.519.6610
plaland@audentestx.com

 

Audentes Therapeutics, Inc.

 

SOURCE Audentes Therapeutics, Inc.


These press releases may also interest you

at 04:21
The new cooperation supports the international utility sector in implementing renewable energy and energy storage solutions into their grids   VDE Association, one of the leading technical associations based in Germany, and Clarion Energy, one of...

at 04:09
Donuts Inc., the global leader in high-quality, new top-level Internet domains, today announced the re-launch of the .travel top-level domain (TLD), which it had acquired earlier this year. Donuts has simplified the registration process, making it...

at 04:00
Aptos Engage Europe 2018 - TXT Retail, an Aptos Company, announced today that the European online retailer and mail order specialist Atlas for Men has successfully implemented the TXTPLM (product lifecycle management) solution to support all phases...

at 04:00
XM Cyber, founded by top executives from Israel's cyber intelligence community and provider of the first fully automated APT (Advanced Persistent Threat) simulation and remediation platform, today announced that it was selected among hundreds of...

at 04:00
CAMBRIDGE, Mass., June 21, 2018 /PRNewswire-PRWeb/ --  World Economic Forum on Thursday announced its selection of the world's 61 most promising Technology Pioneers 2018, the most diverse class of such pioneers ever. Companies were selected for...

at 04:00
World Economic Forum on Thursday announced its selection of the world's 61 most promising Technology Pioneers 2018, the most diverse class of such pioneers ever. Companies were selected for their potential to "transform society and industry" and...




News published on 8 march 2018 at 16:01 and distributed by: