Global Acute Decompensated Heart Failure Forecast and Market Analysis to 2034: Recent Pipeline Discontinuations and Negative Trial Results Have Limited the Future Growth
Acute decompensated heart failure (ADHF) is defined as the sudden worsening of heart failure symptoms (mainly edema, dyspnea, and fatigue), which results in severe respiratory distress. ADHF is categorized into hemodynamic stages based on the degree of perfusion and pulmonary capillary wedge pressure. Despite improvements in treatment, ADHF is a burdensome disease associated with high hospitalization and mortality rates in the elderly population.
Recent events and opinion
Recent pipeline discontinuations and negative trial results have limited the future growth of the ADHF market.
ADHF treatment is focused on hemodynamic stabilization and alleviation of symptoms.
The author estimates that in 2016, there were 1.2 million diagnosed incident cases of ADHF in the US, Japan, and five major EU markets.
Negative results of the LEVO-CTS trial will prevent expansion of Simdax into the low cardiac output syndrome market.
The discontinuations of ularitide and Reasanz dramatically reduce the number of agents in development for ADHF.
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