Chronic myeloid leukemia (CML), also known as chronic myelogenous leukemia, is a myeloproliferative disorder characterized by a single cytogenetic hallmark: the chromosomal translocation t(9;22)(q34;q11), known as the Philadelphia (Ph) chromosome. In a small minority of patients who exhibit the characteristics of CML, the Ph chromosome cannot be detected - this is referred to as Ph-negative CML, or atypical CML.
Market Snapshot
The CML market will experience a short period of growth followed by a decline in sales due to the onset of generic competition.
The largest unmet needs in CML are overcoming TKI resistance and addressing patients with accelerated or blast phase disease.
The number of incident chronic myeloid leukemia cases is expected to increase by 25% over the next 20 years.
Generic imatinib will dominate first-line treatment as Sprycel and Tasigna compete for market share in the second line.
Asciminib is currently the primary candidate in the pipeline, and may benefit patients progressing on available TKIs.
Key Topics Covered:
Forecast: Chronic Myeloid Leukemia
Executive Summary
Market Overview And Trends
Market Definition And Methodology
Asciminib
Bosulif (Bosutinib)
Gleevec (Imatinib)
Iclusig (Ponatinib)
Sprycel (Dasatinib)
Synribo (Omacetaxine Mepesuccinate)
Tasigna (Nilotinib)
Primary Research Methodology
Treatment: Chronic Myeloid Leukemia
Executive Summary
Primary Research Methodology
Disease Definition And Diagnosis
Patient Segmentation
Current Treatment Options
Prescribing Trends
Epidemiology: Chronic Myeloid Leukemia In The Us, Japan, And 5EU
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