Global Chiral Technology Industry

NEW YORK, Feb. 23, 2017 /PRNewswire/ -- This report analyzes the worldwide markets for Chiral Technology in US$ Thousand by the following

Products: Intermediates, Analytical, and Others. The End Use markets also analyzed in the report include Pharmaceuticals, and Agrochemicals. The report provides separate comprehensive analytics for the US, Japan, Europe, and Rest of World. Annual estimates and forecasts are provided for the period 2015 through 2022. Also, a six-year historic analysis is provided for these markets. Market data and analytics are derived from primary and secondary research. Company profiles are primarily based on public domain information including company URLs. The report profiles 31 companies including many key and niche players such as -


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Agilent Technologies, Inc.
Albemarle Corporation
BASF SE
Cambrex Corporation
Chiral Quest (Suzhou) Co., Ltd.



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I. INTRODUCTION, METHODOLOGY & PRODUCT DEFINITIONS

Study Reliability and Reporting Limitations I-1 Disclaimers.............. I-2 Data Interpretation & Reporting Level I-2 Quantitative Techniques & Analytics I-3 Product Definitions and Scope of Study I-3 Chiral Technology Enabling Products I-4 Chiral Intermediates..............I-4 Analytical Products..............I-4 Other Products.............. I-4 Chiral Technology End-Use Markets I-4 Pharmaceuticals.............. I-4 Agrochemicals.............. I-4

II. EXECUTIVE SUMMARY

1. INDUSTRY OVERVIEW.............. II-1 Bright Outlook for the Global Chiral Technology Market II-1 Good Tidings for Chiral Technology II-1 Global Market Outlook..............II-2 Developed Markets: Traditional Revenue Contributors II-3 Developing Countries Turbo Charge Future Market Growth II-3 Table 1: Global Chiral Technology Market - Geographic Regions Ranked by CAGR (Value) for 2015-2022: Rest of World, US, Japan, and Europe (includes corresponding Graph/Chart) II-3 Chiral Intermediates Garner a Larger Pie II-3 Table 2: World Chiral Technology Enabling Products Market by Segment (2016): Percentage Share Breakdown by Value Sales for Chiral Intermediates, Chiral Analytical Products, and Others (includes corresponding Graph/Chart) II-4 Pharmaceuticals: The Largest End-Use Application Domain II-4 Chiral Chromatography Market Continues to Gain Momentum II-4 Emerging Regions to Drive Demand for Chiral Chromatography Columns.............. II-5 Chiral Separation Registers Impressive Growth II-6 Chiral Separation Column Market to Experience Healthy Growth II-6 SFC Holds Tremendous Potential..............II-7

2. MARKET TRENDS, DRIVERS & ISSUES II-8 Chiral Technology Plays a Pivotal Role in the Pharmaceutical Industry.............. II-8 Access to Extensive Range of Enzymes Drive Biocatalyst Use for API Synthesis.............. II-9 Sustainable Chiral Chemistry..............II-9 Progress in Molecular Engineering II-9 Availability to Wide Range of Enzymes II-10 Focus on Synthetic Biology..............II-10 Chemo-Catalysis to Retain Significance II-11 Cascade Organocatalysis..............II-11 Advancements and Challenges Related to Chiral Separation II-11 Chiral Analysis Emerges as Critical Step for Pharmaceutical Industry.............. II-12 Single Enantiomer Drugs Gain Prominence II-12 Demand for Chiral-based Therapeutic Drugs Augments Growth II-13 New Legislations Push Chiral Technology Demand II-13 Organizations Extend Approaches..............II-13 Companies' Association with Universities II-13 Increasing Reliance on Generic Approaches II-13 Predominant Use of Polysaccharides Derivatives as CSPs II-14 Automation: Introduction of Instruments Supporting Chiral Processes, a Growing Trend..............II-14 Researchers Explore Methods to Achieve Large-Scale Synthesis of Single-Structure SWCNTs..............II-14 Key Concerns Hindering Growth of Chiral Technology II-15 Limitations of Chiral Separation Methods II-15

3. TECHNOLOGICAL ADVANCEMENTS..............II-16 CHAIN Biotechnology Concludes Ambitious Research Project II-16 Researchers Add Chiral Organocatalyst to Activate C-C Single Bond II-16 Researchers Focus on New Technique for Chiral Separation II-17 Chiral Phosphines to Aid Synthesis of Asymmetric Reactions II-17 Role of Molecular Propeller Effect in Chiral Separation/Analysis II-18 Biocatalysis Witnesses Increasing Significance in Development through Production of Novel Compounds II-18 Increasing Significance of Biocatalysis II-19 Researchers Develop HPLC Technique for Direct Enantioseparation of ß-Blockers II-19

4. CHIRAL TECHNOLOGY.............. II-21 An Insight into Chiral Technology II-21 Techniques Used for Achieving Single-Isomers II-21 Importance and Advancements..............II-22

5. CHIRAL TECHNOLOGY - AN OVERVIEW II-23 Definitions.............. II-23 Chiral Technology Enabling Products II-23 Chiral Intermediates..............II-23 Analytical Products..............II-23 Other Products.............. II-23 Chiral Technology End-Use Markets II-24 Pharmaceuticals.............. II-24 Agrochemicals.............. II-24 Description.............. II-24 Functioning of Chiral Molecules..............II-25 Chiral Preparation Process..............II-25 Traditional Methods.............. II-25 Processes.............. II-25 Market Drivers.............. II-25 Inhibitor.............. II-25 Biological Methods..............II-26 Processes.............. II-26 Market Drivers.............. II-26 Inhibitor.............. II-26 Asymmetric Methods..............II-26 Processes.............. II-26 Market Drivers.............. II-26 Inhibitor.............. II-26 Chiral Separation.............. II-26 Factors Influencing the Efficacy of Chiral Separations II-27 Recent Approaches in Chiral Separation II-27 Alternatives to Standard Methods II-27 Chromatography - The Widely Used Method for Separation II-28 How it Works?.............. II-28 Chiral Mobile Phase Additive (CMPA) II-29 Chiral Stationary Phase (CSP) II-29 List of Select Generic Versions of Derivatized Amylose and Cellulose Phases..............II-30 Types of CSPs.............. II-31 Macrocyclic Glycoprotein CSPs II-31 Cyclodextrin CSPs..............II-31 Cyclofructan CSPs..............II-31 Challenges and Novel Concepts in the Development of Chiral Stationary Phases..............II-31 Novel Concepts..............II-32 Chiral Recognition..............II-32 Protein Chiral Stationary Phases II-32 Carbohydrate Columns..............II-33 Pirkle Columns.............. II-33 Crystallization.............. II-33 Solvent Extraction.............. II-34 Kinetic Resolution.............. II-34 Capillary Electrophoresis..............II-34 Receptor Based Resolution..............II-35 Miscellaneous Separative Techniques II-35 Chiral Synthesis.............. II-35

6. CHIRAL TECHNOLOGY - DEVELOPMENT VIS-A-VIS ACQUISITION II-36 In-House Creation & Development..............II-36 Acquisition of Technology..............II-36 "Economics" of Chiral Technology II-37

7. CHIRAL ANALYSIS.............. II-38 Chiral Analysis: A Primer..............II-38 Chiral Analysis Products..............II-38 Chiral Analytical Chromatography II-38 Chiral Liquid Chromatography..............II-38 Supercritical Fluid Chromatography - Substitute to LC for Enantiomer Separations..............II-39 Chiral Gas Chromatography..............II-39 Chiral Simulated Moving Bed Chromatography II-39 Partition Chromatography..............II-39 Adsorption Chromatography..............II-40 Computer Assisted Resolution..............II-40 Chiral Polarimetry..............II-40 Other Chiral Analytical Techniques II-40 Calorimetry.............. II-40 Differential Scanning Calorimetry (DSC) II-41 Enzymatic Assay.............. II-41 Immunoassay.............. II-41 Isotope Dilution.............. II-41 Nuclear Magnetic Resonance (NMR) II-42 X-Ray Crystallography..............II-42

8. APPLICATION MARKETS..............II-43 Pharmaceuticals - The Largest Market II-43 Changing Face of the Pharmaceutical Industry: A Review II-43 Analysis of Chiral Drugs..............II-43 Select Companies Involved in Chiral Technology Market II-44 Select Single-Enantiomer Drugs Worldwide II-45 Drugs Built on Chiral Technology II-45 Analgesics.............. II-45 Anesthetics.............. II-46 Anti-Infective Products..............II-46 Cardiovascular System (CVS) Products II-46 Angiotensin-Converting Enzyme (ACE) Inhibitors II-46 Beta-Blockers.............. II-46 Calcium Channel Blockers..............II-47 Diuretics.............. II-47 Vasodilators.............. II-47 Central Nervous System (CNS) Agents II-47 Anticonvulsants.............. II-47 Sedatives and Tranquilizers..............II-47 Stimulants and Antidepressants II-47 Oncogenic (Cancer-Treatment) Products II-48 Biochemicals.............. II-48 Oligonucleotides.............. II-48 Oxyacids.............. II-48 Amino Acids.............. II-49 Alanine Racemase Chiral Analogue: A Breakthrough Chiral Converting Agent.............. II-49 Commercial Development..............II-49 Scope.............. II-50 Sugars and Other Oligosaccharides II-50 Vitamins.............. II-50 Peptides.............. II-51 Pesticides - A Thriving Market II-51 Herbicides.............. II-52 Insecticides.............. II-52 Fungicides.............. II-52 Other Products.............. II-53 Liquid Crystals.............. II-53 Flavor and Aroma Chemicals..............II-53

9. CHIRAL ISOMERISM.............. II-54 Organic Chemical Isomerism Types II-54 Structural Isomerism..............II-54 Chain Isomerism.............. II-54 Position Isomerism..............II-54 Functional Group Isomerism..............II-54 Stereoisomerism.............. II-54 Dynamic Isomerism (Tautomerism) II-55 Patents.............. II-55

10. REGULATORY & ENVIRONMENTAL ISSUES - A REVIEW II-56

11. PRODUCT INTRODUCTIONS/INNOVATIONS II-57 Phenomenex Unveils Lux i-Cellulose-5 Chiral Columns II-57 Chiral Technologies Launches CHIRALPAK® IG II-57 Phenomenex Introduces Amylose-1 Chiral Stationary Phase II-57 Regis Technologies Extends Chiral Column Product Line II-57 Chiral Technologies Unveils CHIRALFLASH MPLC Columns II-57 Phenomenex Extends Lux Chiral Bulk Media Line with Lux Cellulose-3 and Cellulose-4..............II-58 Chiral Technologies Introduces i-CHIRAL 4 II-58

12. RECENT INDUSTRY ACTIVITY..............II-59 Chiral Technologies and GreenCentre Canada Inks Agreement II-59 Chiral Technologies Partners with Strem Chemicals II-59 Jingbo Agrochemical Opens High Chiral Ratio Indoxacarb Technical Manufacturing Plant II-59 Johnson Matthey Takes Over Pharmorphix II-59 Merck Snaps Up Sigma-Aldrich..............II-59 Nagase America Partners with Aspira Scientific II-59 SAFC Partners with BioTools..............II-60 Chiral Technologies Inks Agreement with Sagu Chile II-60 Johnson Matthey Catalysis and Chiral Technologies Expand Ligand Manufacturing Capability II-60

13. FOCUS ON SELECT PLAYERS..............II-61 Agilent Technologies, Inc. (USA) II-61 Albemarle Corporation (USA)..............II-61 BASF SE (Germany).............. II-62 Cambrex Corporation (USA)..............II-62 Chiral Quest (Suzhou) Co., Ltd. (China) II-62 Chiral Technologies, Inc. (USA)..............II-63 Daicel Corporation (Japan)..............II-63 Johnson Matthey PLC (UK)..............II-64 Phenomenex, Inc. (USA)..............II-64 Regis Technologies, Inc. (USA) II-64 Shasun Pharmaceuticals Limited (India) II-65 Shimadzu Corporation (Japan)..............II-65 Sigma Aldrich Corp. (USA)..............II-66 Solvias AG (Switzerland)..............II-66 Thermo Fisher Scientific, Inc. (USA) II-67 YMC America, Inc. (USA)..............II-67

14. GLOBAL MARKET PERSPECTIVE..............II-68 Table 3: World Recent Past, Current & Future Analysis for Chiral Technology Enabling Products by Geographic Region - US, Japan, Europe, and Rest of World Markets Independently Analyzed with Annual Sales Figures in US$ Thousand for Years 2015 through 2022 (includes corresponding Graph/Chart) II-68

Table 4: World Historic Review for Chiral Technology Enabling Products by Geographic Region - US, Japan, Europe, and Rest of World Markets Independently Analyzed with Annual Sales Figures in US$ Thousand for Years 2009 through 2014 (includes corresponding Graph/Chart)..............II-69

Table 5: World 14-Year Perspective for Chiral Technology Enabling Products by Geographic Region - Percentage Breakdown of Value Sales for US, Japan, Europe, and Rest of World Markets for Years 2009, 2016 & 2022 (includes corresponding Graph/Chart).............. II-70

Table 6: World Recent Past, Current & Future Analysis for Chiral Intermediates by Geographic Region - US, Japan, Europe, and Rest of World Markets Independently Analyzed with Annual Sales Figures in US$ Thousand for Years 2015 through 2022 (includes corresponding Graph/Chart) II-71

Table 7: World Historic Review for Chiral Intermediates by Geographic Region - US, Japan, Europe, and Rest of World Markets Independently Analyzed with Annual Sales Figures in US$ Thousand for Years 2009 through 2014 (includes corresponding Graph/Chart)..............II-72

Table 8: World 14-Year Perspective for Chiral Intermediates by Geographic Region - Percentage Breakdown of Value Sales for US, Japan, Europe, and Rest of World Markets for Years 2009, 2016 & 2022 (includes corresponding Graph/Chart) II-73

Table 9: World Recent Past, Current & Future Analysis for Chiral Analytical Products by Geographic Region - US, Japan, Europe, and Rest of World Markets Independently Analyzed with Annual Sales Figures in US$ Thousand for Years 2015 through 2022 (includes corresponding Graph/Chart) II-74

Table 10: World Historic Review for Chiral Analytical Products by Geographic Region - US, Japan, Europe, and Rest of World Markets Independently Analyzed with Annual Sales Figures in US$ Thousand for Years 2009 through 2014 (includes corresponding Graph/Chart)..............II-75

Table 11: World 14-Year Perspective for Chiral Analytical Products by Geographic Region - Percentage Breakdown of Value Sales for US, Japan, Europe, and Rest of World Markets for Years 2009, 2016 & 2022 (includes corresponding Graph/Chart) II-76

Table 12: World Recent Past, Current & Future Analysis for Other Chiral Technology Enabling Products by Geographic Region - US, Japan, Europe, and Rest of World Markets Independently Analyzed with Annual Sales Figures in US$ Thousand for Years 2015 through 2022 (includes corresponding Graph/Chart) II-77

Table 13: World Historic Review for Other Chiral Technology Enabling Products by Geographic Region - US, Japan, Europe, and Rest of World Markets Independently Analyzed with Annual Sales Figures in US$ Thousand for Years 2009 through 2014 (includes corresponding Graph/Chart) II-78

Table 14: World 14-Year Perspective for Other Chiral Technology Enabling Products by Geographic Region - Percentage Breakdown of Value Sales for US, Japan, Europe, and Rest of World Markets for Years 2009, 2016 & 2022 (includes corresponding Graph/Chart)..............II-79

Table 15: World Recent Past, Current & Future Analysis for Chiral Technology in Pharmaceuticals by Geographic Region - US, Japan, Europe, and Rest of World Markets Independently Analyzed with Annual Sales Figures in US$ Thousand for Years 2015 through 2022 (includes corresponding Graph/Chart) II-80

Table 16: World Historic Review for Chiral Technology in Pharmaceuticals by Geographic Region - US, Japan, Europe, and Rest of World Markets Independently Analyzed with Annual Sales Figures in US$ Thousand for Years 2009 through 2014 (includes corresponding Graph/Chart)..............II-81

Table 17: World 14-Year Perspective for Chiral Technology in Pharmaceuticals by Geographic Region - Percentage Breakdown of Value Sales for US, Japan, Europe, and Rest of World Markets for Years 2009, 2016 & 2022 (includes corresponding Graph/Chart).............. II-82

Table 18: World Recent Past, Current & Future Analysis for Chiral Technology in Agrochemicals by Geographic Region - US, Japan, Europe, and Rest of World Markets Independently Analyzed with Annual Sales Figures in US$ Thousand for Years 2015 through 2022 (includes corresponding Graph/Chart) II-83

Table 19: World Historic Review for Chiral Technology in Agrochemicals by Geographic Region - US, Japan, Europe, and Rest of World Markets Independently Analyzed with Annual Sales Figures in US$ Thousand for Years 2009 through 2014 (includes corresponding Graph/Chart)..............II-84

Table 20: World 14-Year Perspective for Chiral Technology in Agrochemicals by Geographic Region - Percentage Breakdown of Value Sales for US, Japan, Europe, and Rest of World Markets for Years 2009, 2016 & 2022 (includes corresponding Graph/Chart).............. II-85

III. MARKET

1. THE UNITED STATES.............. III-1 A.Market Analysis.............. III-1 Overview.............. III-1 Product Launches..............III-1 Strategic Corporate Developments III-3 Select Key Players..............III-3 B.Market Analytics..............III-8 Table 21: The US Recent Past, Current & Future Analysis for Chiral Technology Enabling Products by Segment - Intermediates, Analytical, and Other Markets Independently Analyzed with Annual Sales Figures in US$ Thousand for Years 2015 through 2022 (includes corresponding Graph/Chart) III-8

Table 22: The US Historic Review for Chiral Technology Enabling Products by Segment - Intermediates, Analytical, and Other Markets Independently Analyzed with Annual Sales Figures in US$ Thousand for Years 2009 through 2014 (includes corresponding Graph/Chart) III-9

Table 23: The US 14-Year Perspective for Chiral Technology Enabling Products by Segment - Percentage Breakdown of Value Sales for Intermediates, Analytical, and Other Markets for Years 2009, 2016 & 2022 (includes corresponding Graph/Chart) III-10

Table 24: The US Recent Past, Current & Future Analysis for Chiral Technology by End-Use Application - Pharmaceuticals, and Agrochemicals Markets Independently Analyzed with Annual Sales Figures in US$ Thousand for Years 2015 through 2022 (includes corresponding Graph/Chart) III-11

Table 25: The US Historic Review for Chiral Technology by End-Use Application - Pharmaceuticals, and Agrochemicals Markets Independently Analyzed with Annual Sales Figures in US$ Thousand for Years 2009 through 2014 (includes corresponding Graph/Chart)..............III-12

Table 26: The US 14-Year Perspective for Chiral Technology by End-Use Application - Percentage Breakdown of Value Sales for Pharmaceuticals, and Agrochemicals Markets for Years 2009, 2016 & 2022 (includes corresponding Graph/Chart) III-13

2. JAPAN.............. III-14 A.Market Analysis.............. III-14 Select Key Players..............III-14 B.Market Analytics..............III-16 Table 27: Japanese Recent Past, Current & Future Analysis for Chiral Technology Enabling Products by Segment - Intermediates, Analytical, and Other Markets Independently Analyzed with Annual Sales Figures in US$ Thousand for Years 2015 through 2022 (includes corresponding Graph/Chart) III-16

Table 28: Japanese Historic Review for Chiral Technology Enabling Products by Segment - Intermediates, Analytical, and Other Markets Independently Analyzed with Annual Sales Figures in US$ Thousand for Years 2009 through 2014 (includes corresponding Graph/Chart) III-17

Table 29: Japanese 14-Year Perspective for Chiral Technology Enabling Products by Segment - Percentage Breakdown of Value Sales for Intermediates, Analytical, and Other Markets for Years 2009, 2016 & 2022 (includes corresponding Graph/Chart) III-18

Table 30: Japanese Recent Past, Current & Future Analysis for Chiral Technology by End-Use Application - Pharmaceuticals, and Agrochemicals Markets Independently Analyzed with Annual Sales Figures in US$ Thousand for Years 2015 through 2022 (includes corresponding Graph/Chart) III-19

Table 31: Japanese Historic Review for Chiral Technology by End-Use Application - Pharmaceuticals, and Agrochemicals Markets Independently Analyzed with Annual Sales Figures in US$ Thousand for Years 2009 through 2014 (includes corresponding Graph/Chart)..............III-20

Table 32: Japanese 14-Year Perspective for Chiral Technology by End-Use Application - Percentage Breakdown of Value Sales for Pharmaceuticals, and Agrochemicals Markets for Years 2009, 2016 & 2022 (includes corresponding Graph/Chart) III-21

3. EUROPE.............. III-22 A.Market Analysis.............. III-22 Overview.............. III-22 Strategic Corporate Developments III-22 Select Key Players..............III-23 B.Market Analytics..............III-24 Table 33: European Recent Past, Current & Future Analysis for Chiral Technology Enabling Products by Segment - Intermediates, Analytical, and Other Markets Independently Analyzed with Annual Sales Figures in US$ Thousand for Years 2015 through 2022 (includes corresponding Graph/Chart) III-24

Table 34: European Historic Review for Chiral Technology Enabling Products by Segment - Intermediates, Analytical, and Other Markets Independently Analyzed with Annual Sales Figures in US$ Thousand for Years 2009 through 2014 (includes corresponding Graph/Chart) III-25

Table 35: European 14-Year Perspective for Chiral Technology Enabling Products by Segment - Percentage Breakdown of Value Sales for Intermediates, Analytical, and Other Markets for Years 2009, 2016 & 2022 (includes corresponding Graph/Chart) III-26

Table 36: European Recent Past, Current & Future Analysis for Chiral Technology by End-Use Application - Pharmaceuticals, and Agrochemicals Markets Independently Analyzed with Annual Sales Figures in US$ Thousand for Years 2015 through 2022 (includes corresponding Graph/Chart) III-27

Table 37: European Historic Review for Chiral Technology by End-Use Application - Pharmaceuticals, and Agrochemicals Markets Independently Analyzed with Annual Sales Figures in US$ Thousand for Years 2009 through 2014 (includes corresponding Graph/Chart)..............III-28

Table 38: European 14-Year Perspective for Chiral Technology by End-Use Application - Percentage Breakdown of Value Sales for Pharmaceuticals, and Agrochemicals Markets for Years 2009, 2016 & 2022 (includes corresponding Graph/Chart) III-29

4. REST OF WORLD.............. III-30 A.Market Analysis.............. III-30 China-A Hub for Pharmaceutical Manufacturing III-30 Strategic Corporate Developments III-30 Select Key Players..............III-31 B.Market Analytics..............III-32 Table 39: Rest of World Recent Past, Current & Future Analysis for Chiral Technology Enabling Products by Segment - Intermediates, Analytical, and Other Markets Independently Analyzed with Annual Sales Figures in US$ Thousand for Years 2015 through 2022 (includes corresponding Graph/Chart) III-32

Table 40: Rest of World Historic Review for Chiral Technology Enabling Products by Segment - Intermediates, Analytical, and Other Markets Independently Analyzed with Annual Sales Figures in US$ Thousand for Years 2009 through 2014 (includes corresponding Graph/Chart) III-33

Table 41: Rest of World 14-Year Perspective for Chiral Technology Enabling Products by Segment - Percentage Breakdown of Value Sales for Intermediates, Analytical, and Other Markets for Years 2009, 2016 & 2022 (includes corresponding Graph/Chart)..............III-34

Table 42: Rest of World Recent Past, Current & Future Analysis for Chiral Technology by End-Use Application - Pharmaceuticals, and Agrochemicals Markets Independently Analyzed with Annual Sales Figures in US$ Thousand for Years 2015 through 2022 (includes corresponding Graph/Chart) III-35

Table 43: Rest of World Historic Review for Chiral Technology by End-Use Application - Pharmaceuticals, and Agrochemicals Markets Independently Analyzed with Annual Sales Figures in US$ Thousand for Years 2009 through 2014 (includes corresponding Graph/Chart) III-36

Table 44: Rest of World 14-Year Perspective for Chiral Technology by End-Use Application - Percentage Breakdown of Value Sales for Pharmaceuticals, and Agrochemicals Markets for Years 2009, 2016 & 2022 (includes corresponding Graph/Chart).............. III-37

IV. COMPETITIVE LANDSCAPE

Total Companies Profiled: 31 (including Divisions/Subsidiaries - 34)

The United States (18) Japan (3) Europe (8) - France (1) - Germany (2) - The United Kingdom (2) - Rest of Europe (3) Asia-Pacific (Excluding Japan) (5)
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