DuPont Pioneer and Broad Institute of MIT and Harvard Join Forces to Enable Democratic Access to CRISPR Licensing in Agriculture

CAMBRIDGE, Mass. and JOHNSTON, Iowa, Oct. 18, 2017 /PRNewswire/ -- DuPont Pioneer and the Broad Institute of MIT and Harvard announced today that they have reached an agreement to jointly provide non-exclusive licenses to foundational CRISPR-Cas9 intellectual property under their respective control for use in commercial agricultural research and product development. These two major CRISPR-Cas9 license holders are coming together with the shared goal of enabling all entities wanting to apply the technology for agricultural applications with a full range of CRISPR-Cas9 tools. Such foundational intellectual property (IP) for CRISPR-Cas9 technology will be freely available to universities and nonprofit organizations for academic research. Pioneer is a business unit of the Agriculture Division of DowDuPonttm.

"The promise of CRISPR-Cas9 technology in the hands of many will result in a wide array of benefits for the global food supply ranging from higher and more stable yields of grains, fruits and vegetables for farmers; more nutritious, healthier and affordable foods for consumers; and, improved sustainability of agricultural systems for society," said Neal Gutterson, vice president of Research & Development at DuPont Pioneer. "It is profoundly important to ensure that this technology is made widely available for agriculture. By partnering with the Broad Institute, together we can maximize access to CRISPR-Cas9 around the world for the greater good."

"When DuPont Pioneer initially approached us to secure a license for commercial research, we both saw a unique opportunity to provide much broader access to the technology for agriculture," said Eric Lander, president and founding director of the Broad Institute. "We applaud DuPont Pioneer for its commitment to advancing research and commercialization to accelerate progress in agriculture."

The complex CRISPR licensing landscape includes patents and patent applications from multiple parties. Entities often desire access to comprehensive IP, to ensure their ability to apply the scientific tools as widely as possible. To enable such access, Pioneer and Broad Institute have agreed on a joint non-exclusive licensing framework for agricultural use that (i) continues to provide non-exclusive access to IP from Broad Institute co-owned with its collaborators (including Harvard University, the Massachusetts Institute of Technology, New York Genome Center, New York University, The Rockefeller University, and the University of Iowa), and (ii) provides non-exclusive access to foundational IP from Pioneer and to IP from the licenses that Pioneer gained access through Caribou Biosciences, ERS Genomics and Vilnius University. License limitations exclude certain CRISPR technology applications, including for gene drive or tobacco products for human use.

Broad and Pioneer continue to retain the right to grant independent, non-exclusive licenses for the CRISPR-Cas9 IP that each institution controls to any interested entity.

To inquire about a license, commercial users should email Pioneer at [email protected] or visit the Broad website or contact [email protected]. Academic and nonprofit researchers do not require a license to use the technology for research.

Learn more about CRISPR-Cas applications in agriculture at http://crisprcas.pioneer.com

Learn more about the Broad Institute's efforts to offer CRISPR tools for agriculture on the Broad website.

About the Broad Institute of MIT and Harvard
Broad Institute of MIT and Harvard was launched in 2004 to empower this generation of creative scientists to transform medicine. The Broad Institute seeks to describe all the molecular components of life and their connections; discover the molecular basis of major human diseases; develop effective new approaches to diagnostics and therapeutics; and disseminate discoveries, tools, methods, and data openly to the entire scientific community.

Founded by MIT, Harvard, Harvard-affiliated hospitals, and the visionary Los Angeles philanthropists Eli and Edythe L. Broad, the Broad Institute includes faculty, professional staff, and students from throughout the MIT and Harvard biomedical research communities and beyond, with collaborations spanning over a hundred private and public institutions in more than 40 countries worldwide. For further information about the Broad Institute, go to http://www.broadinstitute.org/.

About DuPont Pioneer
DuPont Pioneer, a business unit of DowDuPont Agriculture Division, is the world's leading developer and supplier of advanced plant genetics, providing high-quality seeds to farmers in more than 90 countries. Pioneer provides agronomic support and services to help increase farmer productivity and profitability and strives to develop sustainable agricultural systems for people everywhere. Science with Service Delivering Success^®.

About DowDuPont Agriculture Division
DowDuPont Agriculture, a business division of DowDuPont (NYSE: DWDP), combines the strengths of DuPont Pioneer, DuPont Crop Protection and Dow AgroSciences. Together, the Agriculture division provides growers around the world with the most complete portfolio in the industry, developed through a robust research pipeline across germplasm, biotech traits and crop protection. DowDuPont Agriculture is committed to delivering innovation, helping growers increase productivity and ensuring food security for a growing global population. DowDuPont intends to separate the Agriculture division into an independent, publicly traded company. More information can be found at www.dow-dupont.com. 

Cautionary Statement About Forward-Looking Statements
This communication contains "forward-looking statements" within the meaning of the federal securities laws, including Section 27A of the Securities Act of 1933, as amended, and Section 21E of the Securities Exchange Act of 1934, as amended. In this context, forward-looking statements often address expected future business and financial performance and financial condition, and often contain words such as "expect," "anticipate," "intend," "plan," "believe," "seek," "see," "will," "would," "target," similar expressions, and variations or negatives of these words.

On December 11, 2015, The Dow Chemical Company ("Dow") and E. I. du Pont de Nemours and Company ("DuPont") announced entry into an Agreement and Plan of Merger, as amended on March 31, 2017, (the "Merger Agreement") under which the companies would combine in an all-stock merger of equals transaction (the "Merger Transaction"). Effective August 31, 2017, the Merger Transaction was completed and each of Dow and DuPont became subsidiaries of DowDuPont Inc. ("DowDuPont"). For more information, please see each of DowDuPont's, Dow's and DuPont's latest annual, quarterly and current reports on Forms 10-K, 10-Q and 8-K, as the case may be, and the joint proxy statement/prospectus included in the registration statement on Form S-4 filed by DowDuPont with the SEC on March 1, 2016 (File No. 333-209869), as last amended on June 7, 2016, and declared effective by the SEC on June 9, 2016 (the "Registration Statement") in connection with the Merger Transaction.

Forward-looking statements by their nature address matters that are, to different degrees, uncertain, including the intended separation of DowDuPont's agriculture, materials science and specialty products businesses in one or more tax efficient transactions on anticipated terms (the "Intended Business Separations"). Forward-looking statements are not guarantees of future performance and are based on certain assumptions and expectations of future events which may not be realized. Forward-looking statements also involve risks and uncertainties, many of which are beyond the company's control. Some of the important factors that could cause DowDuPont's, Dow's or DuPont's actual results to differ materially from those projected in any such forward-looking statements include, but are not limited to: (i) successful integration of the respective agriculture, materials science and specialty products businesses of Dow and DuPont, including anticipated tax treatment, unforeseen liabilities, future capital expenditures, revenues, expenses, earnings, productivity actions, economic performance, indebtedness, financial condition, losses, future prospects, business and management strategies for the management, expansion and growth of the combined operations; (ii) impact of the divestitures required as a condition to consummation of the Merger Transaction as well as other conditional commitments; (iii) achievement of the anticipated synergies by DowDuPont's agriculture, materials science and specialty products businesses; (iv) risks associated with the Intended Business Separations, including those that may result from the comprehensive portfolio review undertaken by the DowDuPont board, changes and timing, including a number of conditions which could delay, prevent or otherwise adversely affect the proposed transactions, including possible issues or delays in obtaining required regulatory approvals or clearances related to the Intended Business Separations, disruptions in the financial markets or other potential barriers; (v) the risk that disruptions from the Intended Business Separations will harm DowDuPont's business (either directly or as conducted by and through Dow or DuPont), including current plans and operations; (vi) the ability to retain and hire key personnel; (vii) potential adverse reactions or changes to business relationships resulting from the completion of the merger or the Intended Business Separations; (viii) uncertainty as to the long-term value of DowDuPont common stock; (ix) continued availability of capital and financing and rating agency actions; (x) legislative, regulatory and economic developments; (xi) potential business uncertainty, including changes to existing business relationships, during the pendency of the Intended Business Separations that could affect the company's financial performance and (xii) unpredictability and severity of catastrophic events, including, but not limited to, acts of terrorism or outbreak of war or hostilities, as well as management's response to any of the aforementioned factors. These risks, as well as other risks associated with the merger and the Intended Business Separations, are more fully discussed in (1) the Registration Statement and (2) the current, periodic and annual reports filed with the SEC by DowDuPont and to the extent incorporated by reference into the Registration Statement, by Dow and DuPont. While the list of factors presented here is, and the list of factors presented in the Registration Statement are, considered representative, no such list should be considered to be a complete statement of all potential risks and uncertainties. Unlisted factors may present significant additional obstacles to the realization of forward-looking statements. Consequences of material differences in results as compared with those anticipated in the forward-looking statements could include, among other things, business disruption, operational problems, financial loss, legal liability to third parties and similar risks, any of which could have a material adverse effect on DowDuPont's, Dow's or DuPont's consolidated financial condition, results of operations, credit rating or liquidity. None of DowDuPont, Dow or DuPont assumes any obligation to publicly provide revisions or updates to any forward-looking statements regarding the proposed transaction and intended business separations, whether as a result of new information, future developments or otherwise, should circumstances change, except as otherwise required by securities and other applicable laws.

10/18/17
^{®, tm, SM} Trademarks and service marks of DuPont, Pioneer or their respective owners.

SOURCE Broad Institute